Ropinirole EP Impurity A HCl CAS 221264-21-7
| CAS No. | 221264-21-7 |
| Molecular Formula | C16H22N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ropinirole EP Impurity A HCl (CAS 221264-21-7) is a certified pharmaceutical impurity reference standard with the molecular formula C16H22N2O2HCl and a molecular weight of 310.82 g/mol.
The molecular framework of Ropinirole EP Impurity A HCl (C16H22N2O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Ropinirole EP Impurity A HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H22N2O2 HCl |
| Molecular Weight | 310.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ropinirole Standards
- Ropinirole Impurity 10 (CAS 101566-00-1)
- Ropinirole Impurity 24 (CAS 1027600-42-5)
- Ropinirole Impurity 27 (CAS 1027600-42-5 (free base))
- Ropinirole EP Impurity A (CAS 102842-51-3)
- Ropinirole EP Impurity D (CAS 106916-16-9)
- Ropinirole Impurity 3 HCl (CAS 1076199-41-1)
- Ropinirole-D14 (CAS 1132746-05-4)
- Ropinirole Impurity 4 (CAS 120427-93-2)
Recommended Standards
- Verapamil Impurity 51 (CAS CATO-C4X-177851)
- Tolvaptan Impurity 62 (CAS 2657689-30-8)
- Fluocortolone Impurity 15 (CAS 34097-16-0)
- Secalciferol (CAS 55721-11-4)
- Piperazine Impurity 20 (CAS 119891-85-9)
- Salmeterol Fluticasone Propionate Mixture (CAS 136112-01-1)
- 1,3-Bis(1-(2-(pyridin-4-yl)ethyl)piperidin-4-yl)propane (CAS 865075-36-1)
- 5-(Bromomethyl)-2-methoxy-3-methylpyridine (CAS 1379340-82-5)
- (2S,4S)-1-(tert-butoxycarbonyl)-4-(m-tolyloxy)pyrrolidine-2-carboxylic acid (CAS 869681-97-0)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com