2-Chloro-1-(4-phenylmethanesulfonylpiperazin-1-yl)ethan-1-one CAS 221289-97-0
| CAS No. | 221289-97-0 |
| Molecular Formula | C13H17ClN2O3S |
| Molecular Weight | 316.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Chloro-1-(4-phenylmethanesulfonylpiperazin-1-yl)ethan-1-one (CAS 221289-97-0), molecular formula C13H17ClN2O3S and molecular weight 316.80 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-1-(4-phenylmethanesulfonylpiperazin-1-yl)ethan-1-one (C13H17ClN2O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C13H17ClN2O3S |
| Molecular Weight | 316.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
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Recommended Standards
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- 1-(chloroacetyl)-4-[(4-methylphenyl)sulfonyl]piperazine (CAS 246514-23-8)
- 2-Methyl-4-(piperidine-1-carboxamido)benzene-1-sulfonyl chloride (CAS 678185-67-6)
- 2-Acetamido-5,6-dihydro-4h-cyclopenta[d]thiazole-4-carboxylic acid (CAS 1219827-65-2)
- 1-(5-Fluoro-2,4-Dinitrophenyl)-4-Methylpiperazine (CAS 928830-73-3)
- Methylergometrine EP Impurity G (CAS 5793-04-4)
- 10-(Naphthalen-1-yl)-9-(4-(naphthalen-1-yl)phenyl)-2-phenylanthracene (CAS 1207252-09-2)
- N1-(2-Hydroxyethyl)-N2-(2-methoxyethyl)oxalamide (CAS 357268-03-2)
- N-(3-Acetylphenyl)-6-ethoxypyridazine-3-carboxamide (CAS 1351585-42-6)
- 1-Methoxy-2-(4-methylphenyl)-1H-imidazo[4,5-b]pyridine (CAS 339026-96-9)
- 5,5'-Bis(5-bromothiophen-2-yl)-4,4'-dihexyl-2,2'-bithiazole (CAS 853722-91-5)
- Indoline-6-carboxylic acid (CAS 732922-86-0)
- Insulin degludec (CAS 844439-96-9)
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