8-Bromo-4-chloro-2-methylquinazoline CAS 221298-75-5
| CAS No. | 221298-75-5 |
| Molecular Formula | C9H6BrClN2 |
| Molecular Weight | 257.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 8-Bromo-4-chloro-2-methylquinazoline (CAS 221298-75-5), a certified reference material (molecular formula C9H6BrClN2, MW 257.51 g/mol) for analytical method development and quality control.
Structurally, 8-Bromo-4-chloro-2-methylquinazoline (C9H6BrClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 257.51 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6BrClN2 |
| Molecular Weight | 257.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 6-Bromo-4-chloro-1-methylphthalazine (CAS 1011291-79-4)
- 6-Bromo-1-chloro-4-methylphthalazine (CAS 1011291-80-7)
- 6-Bromo-1-chloro-2-naphthol (CAS 102169-88-0)
- 3-Bromo-8-chloroquinolin-4-amine (CAS 1065088-37-0)
- 8-Bromo-4-chloro-6-methylquinazoline (CAS 1100207-81-5)
- 4-Bromo-6-chloroquinolin-2-amine (CAS 1136479-34-9)
- 3-bromo-2-chloro-5-methyl[1,6]naphthyridine (CAS 1192263-93-6)
- 5-Bromo-2-chloro-6-cyclopropylnicotinonitrile (CAS 1221792-18-2)
Recommended Standards
- 7-Bromo-4-chloro-5-methylcinnoline (CAS 2759951-05-6)
- 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonyl Chloride (CAS 1269119-14-3)
- 7-Bromo-4-chloro-2-methylquinazoline (CAS 403850-84-0)
- (3-Chloro-4-(3-(dimethylamino)propoxy)phenyl)boronic acid (CAS 1704080-14-7)
- (S)-3-Amino-3-(2,4-dimethoxyphenyl)propanoic acid (CAS 951174-49-5)
- 2-Bromo-3-chloro-5-(trifluoromethyl)aniline (CAS 1805585-12-9)
- 3-Fluoro-2-nitro-N-phenylaniline (CAS 930791-49-4)
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- 8-Methoxy-2-azaspiro[4.5]Decan-3-one (CAS 1566937-03-8)
- N,2-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanamide (CAS 1612174-35-2)
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- Ethyl 2-{4-[4-(benzyloxy)phenyl]-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate (CAS 860784-77-6)
- 3-(3,4-Dimethylphenyl)-3-methoxypropiophenone (CAS 898755-65-2)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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