2,4-Bis(trifluoromethyl)acetyl chloride CAS 221319-34-2
| CAS No. | 221319-34-2 |
| Molecular Formula | C10H5ClF6O |
| Molecular Weight | 290.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,4-Bis(trifluoromethyl)acetyl chloride (CAS 221319-34-2), molecular formula C10H5ClF6O and molecular weight 290.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,4-Bis(trifluoromethyl)acetyl chloride (C10H5ClF6O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2,4-Bis(trifluoromethyl)acetyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF6O |
| Molecular Weight | 290.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | F/Cl-containing |
Related Bis Standards
- 3,5-Bis(trifluoromethyl)phenylacetyl Chloride (CAS 174083-39-7)
- 4-Phenyl-5-(trifluoromethyl)thiophene-2-carbonyl chloride (CAS 208108-75-2)
- 5-(Trifluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1261365-60-9)
- 1-Boc-2-[2-(trifluoromethyl)benzyl]hydrazine (CAS 1690617-00-5)
- 3-(2-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-5,8-methanocinnoline (CAS 918873-46-8)
- 4-(3-(Trifluoromethyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4h)-yl)butanoic acid (CAS 832740-83-7)
- 2-[Methyl-[4-(trifluoromethyl)-1,3-benzothiazol-2-yl]amino]acetic acid (CAS 1421508-23-7)
- 1-((4-(Trifluoromethyl)phenyl)sulfonyl)-1H-pyrrol-3-amine (CAS 1934285-35-4)
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