(E)-3-(4-Fluorophenyl)-2-methylacrylic acid CAS 22138-72-3
| CAS No. | 22138-72-3 |
| Molecular Formula | C10H9FO2 |
| Molecular Weight | 180.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(4-Fluorophenyl)-2-methylacrylic acid.
CATO supplies (E)-3-(4-Fluorophenyl)-2-methylacrylic acid (CAS 22138-72-3), a certified reference material (molecular formula C10H9FO2, MW 180.18 g/mol) for analytical method development and quality control.
The molecular framework of (E)-3-(4-Fluorophenyl)-2-methylacrylic acid (C10H9FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures (E)-3-(4-Fluorophenyl)-2-methylacrylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9FO2 |
| Molecular Weight | 180.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
Related E Standards
- 3-(2-fluorophenyl)but-2-enoic acid (CAS 1130-95-6)
- 2-(3-Fluorophenyl)cyclopropanecarboxylic Acid (CAS 1157561-41-5)
- 1-(2-Fluorophenyl)imidazolidin-2-one (CAS 1190281-65-2)
- 3-(4-fluorophenyl)but-2-enoic acid (CAS 1201-86-1)
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- 4-(3-Fluorophenyl)but-3-enoic acid (CAS 127404-67-5)
- (E)-4-(2-fluorophenyl)but-3-enoic acid (CAS 127406-53-5)
- 1-(2-Fluorophenyl)-1,3-butanedione (CAS 131513-64-9)
Recommended Standards
- (E)-3-(4-fluoro-3-methylphenyl)acrylic acid (CAS 913699-82-8)
- (S)-6-fluoro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 874216-80-5)
- (E)-3-(3-Fluoro-5-methylphenyl)acrylic acid (CAS 773132-32-4)
- [1,3]Thiazolo[5,4-b]pyridine-2-carboxylic acid (CAS 857969-93-8)
- 3-(4-Bromophenyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole (CAS 321679-99-6)
- (2,5-Dichlorophenyl)(tetrahydrofuran-3-yl)methanamine (CAS 1248787-60-1)
- 3-Fluoro-4-iodo-1H-pyrrolo[2,3-b]pyridine (CAS 1352394-59-2)
- 1-Bromo-2,6-dimethoxy-4-iodobenzene (CAS 1318133-20-8)
- (R)-1-(thiophen-3-yl)prop-2-en-1-amine (CAS 1213192-72-3)
- N-(2-(3-Allylureido)phenyl)-2-chlorobenzamide (CAS 1203232-70-5)
- (E)-3-(Dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one (CAS 78090-00-3)
- 9-(3,5-Dihydro-2H-benzo[e][1,4]dioxepin-3-yl)-9H-purin-6-amine (CAS 918304-37-7)
- n1,n1-Diethyl-n2-((5-methylfuran-2-yl)methyl)ethane-1,2-diamine (CAS 937664-12-5)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com