4-Bromo-3-(hydroxymethyl)biphenyl CAS 22156-72-5
| CAS No. | 22156-72-5 |
| Molecular Formula | C13H11BrO |
| Molecular Weight | 263.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromo-3-(hydroxymethyl)biphenyl.
4-Bromo-3-(hydroxymethyl)biphenyl (CAS 22156-72-5), molecular formula C13H11BrO and molecular weight 263.13 g/mol, is a CATO reference standard with documented purity and traceability.
4-Bromo-3-(hydroxymethyl)biphenyl (C13H11BrO) contains a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromo-3-(hydroxymethyl)biphenyl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11BrO |
| Molecular Weight | 263.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Br-containing |
Related Bromo Standards
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- 3-Bromo-N-(pyridin-2-ylmethyl)aniline (CAS 1019599-73-5)
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Recommended Standards
- 4-Bromo-2-methyl-1-phenoxybenzene (CAS 364354-09-6)
- 4'-Bromo-3-methoxy-1,1'-biphenyl (CAS 74447-69-1)
- 4-Bromo-2-methoxybiphenyl (CAS 227305-07-9)
- 4-Bromo-4'-methoxy-1,1'-biphenyl (CAS 58743-83-2)
- N-(4-Aminoquinazolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide (CAS 828930-94-5)
- (2S,3S)-1,2-dimethylpiperidin-3-amine (CAS 2306252-62-8)
- Methyl 5-(p-tolyl)furan-2-carboxylate (CAS 52939-04-5)
- 2-(1H-Inden-2-yl)-5-methylfuran (CAS 291773-42-7)
- 1-[(1-methyl-1H-pyrrol-3-yl)sulfonyl]piperazine (CAS 949654-73-3)
- 1-(5-Fluoro-2-methylphenyl)cyclopentanamine (CAS 1344100-98-6)
- 3-(methoxy)-N-(3,5-dichloro-4-pyridinyl) -4-difluoromethoxy) benzamide (CAS 162401-29-8)
- 2-Bromo-5-chloro-4-(difluoromethoxy)pyridine (CAS 1432754-45-4)
- 2-Bromo-5-methoxyisonicotinic acid (CAS 1256789-55-5)
- Peptide Impurity 26 (CAS 1350456-66-4)
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