Polymyxin B nonapeptide TFA CAS 2220175-42-6
| CAS No. | 2220175-42-6 |
| Molecular Formula | C43H74N14O11 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Polymyxin B nonapeptide TFA (CAS 2220175-42-6) is a high-purity analytical reference standard with the molecular formula C43H74N14O11C2HF3O2 and a molecular weight of 1077.17 g/mol.
The molecular framework of Polymyxin B nonapeptide TFA (C43H74N14O11C2HF3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C43H74N14O11 5*C2HF3O2 |
| Molecular Weight | 1077.17 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 14 |
Related Polymyxin Standards
- Polymyxin B - API Standards (CAS 1404-26-8)
- Polymyxin B Sulfate (CAS 1405-20-5)
- Polymyxin Impurity 56 X Trifluoroacetate (CAS 3034660-94-8 (free base))
- Polymyxin E2 (CAS 30387-41-8)
- Polymyxin Impurity 20 (CAS 343979-23-7)
- Polymyxin B2 (CAS 34503-87-2)
- Polymyxin B2 XTFA Salt (CAS 34503-87-2 (free base))
- Polymyxin B2 Acetate (CAS 34503-87-2（free base）)
Recommended Standards
- Ethyl 5-chloro-6-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 2359663-69-5)
- 3-Ethoxy-4,5-difluorobenzoic acid (CAS 1379315-07-7)
- 2-(6-Amino-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl butyrate (CAS 87970-06-7)
- 1-Cyclopropoxy-3-isopropylbenzene (CAS 1243473-52-0)
- 3,5-dichloro-N-(3-cyanophenyl)benzenecarboximidamide (CAS 339009-81-3)
- 2-(chloromethyl)phenethyl 4-(trifluoromethyl)benzoate (CAS 303187-61-3)
- Veratraldehyde-2-<SUP>13</SUP>C (CAS 1173022-44-0)
- N-(4-(N-(2-Oxo-1,2,3,4-tetrahydroquinolin-6-yl)sulfamoyl)phenyl)butyramide (CAS 922134-00-7)
- 2-Formylphenyl benzenesulfonate (CAS 107189-77-5)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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