Venlafaxine Impurity 81 HCl CAS 2223072-89-5
| CAS No. | 2223072-89-5 |
| Molecular Formula | C15H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Venlafaxine Impurity 81 HCl (CAS 2223072-89-5) is a certified pharmaceutical impurity reference standard with the molecular formula C15H21NOHCl and a molecular weight of 267.80 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Venlafaxine Impurity 81 HCl is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 267.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Venlafaxine Impurity 81 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H21NO HCl |
| Molecular Weight | 267.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Venlafaxine Standards
- Venlafaxine Impurity 58 (CAS 1000377-27-4)
- Venlafaxine Impurity 31 (CAS 1020719-35-0)
- Venlafaxine Impurity 15 (CAS 1021933-95-8)
- Venlafaxine Impurity 33 (CAS 1062607-49-1)
- Venlafaxine Impurity 36 (CAS 1062609-99-7)
- Venlafaxine EP Impurity G (CAS 1076199-92-2)
- Venlafaxine N-Oxide (CAS 1094598-37-4)
- Venlafaxine Impurity 18 (CAS 1168135-16-7)
Recommended Standards
- Fluconazole Impurity 54 (CAS CATO-C4X-101954)
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- rac-Formoterol Impurity 57 HCl (CAS CATO-C4X-152588)
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- 7-Methyltryptophol (CAS 39232-85-4)
- 1,3-Bis(1-methylcyclopropyl)urea (CAS 2044706-57-0)
- 1-Ethyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 53977-49-4)
- 5-(1-Aminoethyl)-2-fluorophenol (CAS 1270485-02-3)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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