1-(Difluoromethoxy)-3-nitrobenzene CAS 22236-07-3
| CAS No. | 22236-07-3 |
| Molecular Formula | C7H5F2NO3 |
| Molecular Weight | 189.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1-(Difluoromethoxy)-3-nitrobenzene (CAS 22236-07-3), a certified reference material (molecular formula C7H5F2NO3, MW 189.12 g/mol) for analytical method development and quality control.
Structurally, 1-(Difluoromethoxy)-3-nitrobenzene (C7H5F2NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 189.12 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5F2NO3 |
| Molecular Weight | 189.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethoxy Standards
- 5-(Difluoromethoxy)picolinic acid (CAS 1174323-34-2)
- 3-(Difluoromethoxy)isonicotinic acid (CAS 1211526-06-5)
- 6-(Difluoromethoxy)nicotinic Acid (CAS 1211535-62-4)
- 3-(Difluoromethoxy)pyridine-2-carboxylic acid (CAS 1211541-12-6)
- 2-(Difluoromethoxy)isonicotinic Acid (CAS 1211581-51-9)
- 2-(Difluoromethoxy)nicotinic Acid (CAS 1211587-59-5)
- 5-(Difluoromethoxy)pyridine-3-carboxylic acid (CAS 1256826-25-1)
- 6-(Difluoromethoxy)picolinic acid (CAS 1522367-81-2)
Recommended Standards
- 1-(Difluoromethoxy)-2-nitrobenzene (CAS 22225-77-0)
- 1-(Difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid (CAS 677761-98-7)
- (4,5-Difluoro-2-nitrophenyl)methanol (CAS 914095-13-9)
- 1,2-Difluoro-3-methoxy-4-nitrobenzene (CAS 66684-60-4)
- N-(3-morpholinopropyl)-4-nitrobenzamide hydrochloride (CAS 1603-33-4)
- 2-Amino-3-fluorobenzene-1-sulfonamide (CAS 1161945-86-3)
- 3-Chloro-2,2-dimethyl-N'-phenylpropanehydrazide (CAS 320422-74-0)
- 2-Amino-2-(pyridin-2-yl)ethan-1-ol hydrochloride (CAS 1269652-50-7)
- 2-(1-Aminocyclopentyl)-5-methoxypyrimidin-4(3H)-one hydrochloride (CAS 2137570-78-4)
- Fenfuram Impurity 17 (CAS 54110-34-8)
- 2-Fluoro-3-(N,N-dimethylaminocarbonyl)phenylboronic acid (CAS 1451391-88-0)
- (+)-Alpha-Pinene (CAS 7785-70-8)
- 2-{[5-(2,6-dimethylphenoxymethyl)-4-phenyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 64013-61-2)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com