2,4-Bis(difluoromethoxy)aniline CAS 22236-14-2
| CAS No. | 22236-14-2 |
| Molecular Formula | C8H7F4NO2 |
| Molecular Weight | 225.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,4-Bis(difluoromethoxy)aniline.
2,4-Bis(difluoromethoxy)aniline (CAS 22236-14-2), molecular formula C8H7F4NO2 and molecular weight 225.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,4-Bis(difluoromethoxy)aniline (C8H7F4NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F4NO2 |
| Molecular Weight | 225.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 3,4-Bis(difluoromethoxy)aniline (CAS 71791-36-1)
- 2-(Difluoromethoxy)-1,3-difluoro-5-nitrobenzene (CAS 1417568-83-2)
- 1-(difluoromethoxy)-2,5-difluoro-4-nitrobenzene (CAS 1803610-49-2)
- 2-(Difluoromethoxy)-3,4-difluoro-1-nitrobenzene (CAS 206546-18-1)
- 3-(Difluoromethoxy)-N-(prop-2-yn-1-yl)benzamide (CAS 1147279-02-4)
- 2-(Difluoromethoxy)-5-propionylbenzonitrile (CAS 1803866-97-8)
- 2-(Difluoromethoxy)-6-propionylbenzonitrile (CAS 1806641-08-6)
- 2-(Difluoromethoxy)-4-fluorobenzoyl chloride (CAS 1261645-42-4)
Recommended Standards
- 2,3,4,5,6-Pentafluorophenyl isothiocyanate (CAS 35923-79-6)
- 3-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)piperidine (CAS 2365173-94-8)
- 2-(Oct-4-en-4-yl)-1,3,6,2-dioxazaborocane (CAS 608534-40-3)
- 1-Bromo-9-fluorononane (CAS 926923-52-6)
- 1-(Pyrrolidin-1-yl)-2-(thieno[2,3-d]pyrimidin-4-ylamino)ethan-1-one (CAS 1197516-18-9)
- 65-61-2 YO2175B15I Acridine Orange Acridine, 3,6-bis(dimethylamino)-, monohydrochloride 3,6-Acridinediamine, N,N,N',N'-tetramethyl-, monohydrochloride N,N,N',N'-Tetramethylacridin-3,6-yldiamine hydrochloride 3,6-Acridinediamine, N3,N3,N6,N6-tetramethyl-, hydrochloride (1:1) C.I. 46005 C.I. Basic Orange 14 Acridine Orange N Acridine Orange R Acridine Orange NO Acridine Orange NS Basic Orange 14 Basic Orange 3RN 3,6-Bis(dimethylamino)acridine hydrochloride CCRIS 736 EINECS 200-614-0 NSC 56324 Rhoduline Orange Rhoduline Orange NO Sumitomo Acridine Orange NO Sumitomo Acridine Orange RK conc UNII-YO2175B15I (CAS 65-61-2)
- 1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (CAS 2031268-80-9)
- 4-Bromo-1-(difluoromethyl)pyrazole (CAS 956477-67-1)
- ethyl 5-methyl-4-oxo-3H,4H-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (CAS 427878-70-4)
- n-Phenyl-1-(pyridin-4-yl)piperidin-4-amine (CAS 1094484-20-4)
- Oxazepam Impurity 2 (CAS 17977-76-3)
- 2,3-Dihydro-2-(iodomethyl)benzofuran (CAS 59152-49-7)
- 3-Chloromethyl-2-hydroxy-6-(trifluoromethyl)pyridine (CAS 1227584-78-2)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com