(1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone CAS 2223749-52-6
| CAS No. | 2223749-52-6 |
| Molecular Formula | C18H19F3N2O3 |
| Molecular Weight | 368.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone.
(1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone (CAS 2223749-52-6) is a high-purity analytical reference standard with the molecular formula C18H19F3N2O3 and a molecular weight of 368.35 g/mol.
The molecular framework of (1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone (C18H19F3N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (1,8-Dioxa-4-azaspiro[5.5]undecan-4-yl)(6-(trifluoromethyl)-1H-indol-2-yl)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H19F3N2O3 |
| Molecular Weight | 368.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dioxa Standards
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-methoxyphenyl)methanone (CAS 898755-79-8)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-methoxyphenyl)methanone (CAS 898755-80-1)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-methoxyphenyl)methanone (CAS 898755-82-3)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-methoxyphenyl)methanone (CAS 898761-38-1)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-methoxyphenyl)methanone (CAS 898761-41-6)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-methoxyphenyl)methanone (CAS 898761-44-9)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-methoxyphenyl)methanone (CAS 898757-49-8)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-methoxyphenyl)methanone (CAS 898757-52-3)
Recommended Standards
- 2-Bromo-3-chloro-4-(difluoromethyl)-5-iodopyridine (CAS 1806932-74-0)
- (2-(Dimethyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)silyl)phenyl)methanol (CAS 947515-75-5)
- 4-Bromo-5-chloro-2-(difluoromethyl)-3-iodopyridine (CAS 1806841-62-2)
- (4R,5R)-4,5-Diphenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (CAS 2757082-86-1)
- 4-Hydroxyphenethylanisate (CAS 87932-34-1)
- 3-(Dimethylamino)-2-methoxyphenol (CAS 1243457-95-5)
- 4-Chloro-5-(chloromethyl)thiazole (CAS 1805561-14-1)
- N-(4-Butylphenyl)-1,3-benzothiazol-2-amine (CAS 380442-81-9)
- 7-Bromo-5-chloro-2-phenyl-1H-benzo[d]imidazole (CAS 16429-41-7)
- N-(3-bromo-4-methoxybenzyl)cyclohexanamine hydrobromide (CAS 1609406-65-6)
- N-Ethyl-5-methyl-3,6-diphenylpyridazin-4-amine (CAS 60326-06-9)
- (1S,2S,4R)-4-Amino-2-fluorocyclohexan-1-ol (CAS 2711860-20-5)
- 2-(2-Chlorophenoxy)aniline (CAS 56966-47-3)
- Tirzepatide Impurity 38 (CAS CATO-C4X-324038)
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