(5-Chloro-6-(3-fluorophenyl)pyridin-3-yl)boronic acid CAS 2225169-53-7
| CAS No. | 2225169-53-7 |
| Molecular Formula | C11H8BClFNO2 |
| Molecular Weight | 251.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(5-Chloro-6-(3-fluorophenyl)pyridin-3-yl)boronic acid (CAS 2225169-53-7), molecular formula C11H8BClFNO2 and molecular weight 251.45 g/mol, is a CATO reference standard with documented purity and traceability.
(5-Chloro-6-(3-fluorophenyl)pyridin-3-yl)boronic acid (C11H8BClFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8BClFNO2 |
| Molecular Weight | 251.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (2-(5-Chloro-2-fluorophenyl)pyridin-4-yl)boronic acid (CAS 1354758-81-8)
- (5-Chloro-6-(2-fluorophenyl)pyridin-3-yl)boronic acid (CAS 2225155-82-6)
- (5-Chloro-6-(4-fluorophenyl)pyridin-3-yl)boronic acid (CAS 2225173-81-7)
- 2-Chloro-4-fluorophenacyl bromide (CAS 61397-54-4)
- 1-Chloro-4-(2,6-dichlorophenyl)butan-2-one (CAS 2097862-03-6)
- 4-Chloro-1-(3,4-dichlorophenyl)butan-1-one (CAS 80212-12-0)
- 6-Chloro-3-hydroxy-3-(trifluoromethyl)indolin-2-one (CAS 108440-32-0)
- 5-Chloro-3-methyl-7-(trifluoromethyl)benzo[d]oxazol-2(3H)-one (CAS 1267061-04-0)
Recommended Standards
- 6,8-Diethyl-5-pentyloctahydroindolizine (CAS 185417-27-0)
- 2,3,4,5,6-Pentamethylphenylmagnesium bromide, 0.5M THF (CAS 91345-58-3)
- 3,4,6-Trichloro-2-nitrobenzonitrile (CAS 2112-14-3)
- 4-tert-Butylbenzylmagnesium bromide 0.25 M in Tetrahydrofuran (CAS 127349-68-2)
- Methyl 2-((1r,4r)-4-(4-(5-aminopyridin-2-yl)phenyl)cyclohexyl)acetate (CAS 956137-23-8)
- 1-(2-Chloro-6-fluorobenzyl)piperidin-3-ol (CAS 415957-98-1)
- 1-Chloro-3,4-difluoro-2-(trifluoromethyl)benzene (CAS 1208076-15-6)
- 4-Chloro-2-cyano-3-fluorophenylisothiocyanate (CAS 1000577-97-8)
- 4-(1-Benzothiophen-2-yl)-2-(1H-pyrrol-1-yl)pyrimidine (CAS 860788-68-7)
- 3,4-Dichloro-5-(cyclopentyloxy)pyridazine (CAS 1346698-12-1)
- 2-Chloro-3-(tributylstannyl)pyrazine (CAS 446285-68-3)
- Methyl 5-cyano-2-nitro-4-(trifluoromethyl)benzoate (CAS 1805121-00-9)
- 3-bromo-7-chloro-1,5-naphthyridine (CAS 1246550-12-8)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com