(1-(4-Fluoro-2-methylphenyl)-1H-pyrazol-4-yl)boronic acid CAS 2225171-90-2
| CAS No. | 2225171-90-2 |
| Molecular Formula | C10H10BFN2O2 |
| Molecular Weight | 220.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (1-(4-Fluoro-2-methylphenyl)-1H-pyrazol-4-yl)boronic acid (CAS 2225171-90-2), a certified reference material (molecular formula C10H10BFN2O2, MW 220.01 g/mol) for analytical method development and quality control.
The molecular framework of (1-(4-Fluoro-2-methylphenyl)-1H-pyrazol-4-yl)boronic acid (C10H10BFN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), (1-(4-Fluoro-2-methylphenyl)-1H-pyrazol-4-yl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10BFN2O2 |
| Molecular Weight | 220.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- [3-fluoro-4-(1H-pyrazol-1-ylmethyl)phenyl]boronic acid (CAS 1333403-67-0)
- (2-Fluoro-4-(2-methyl-1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225175-91-5)
- (2-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225169-60-6)
- (2-Fluoro-4-(4-methyl-1H-pyrazol-1-yl)phenyl)boronic acid (CAS 2225178-48-1)
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- (3-Fluoro-5-(4-methyl-1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225155-55-3)
- (3-Fluoro-5-(4-methyl-1H-pyrazol-1-yl)phenyl)boronic acid (CAS 2225180-88-9)
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