(3-Chloro-5-cyano-2-cyclopropylphenyl)boronic acid CAS 2225178-64-1
| CAS No. | 2225178-64-1 |
| Molecular Formula | C10H9BClNO2 |
| Molecular Weight | 221.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (3-Chloro-5-cyano-2-cyclopropylphenyl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
(3-Chloro-5-cyano-2-cyclopropylphenyl)boronic acid (CAS 2225178-64-1), molecular formula C10H9BClNO2 and molecular weight 221.45 g/mol, is a CATO reference standard with documented purity and traceability.
(3-Chloro-5-cyano-2-cyclopropylphenyl)boronic acid (C10H9BClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H9BClNO2 |
| Molecular Weight | 221.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (4-Chloro-2-methylquinolin-6-yl)boronic acid (CAS 1402238-27-0)
- (2-Chloro-3-cyano-5-cyclopropylphenyl)boronic acid (CAS 2225172-77-8)
- (2-Chloro-4-(1H-pyrrol-1-yl)phenyl)boronic acid (CAS 2225171-67-3)
- (2-Chloro-5-cyano-3-cyclopropylphenyl)boronic acid (CAS 2225179-47-3)
- (2-Chloro-5-cyano-4-cyclopropylphenyl)boronic acid (CAS 2225169-18-4)
- (7-Chloro-8-methylquinolin-6-yl)boronic acid (CAS 2377605-68-8)
- [2-Chloro-4-(1-cyanocyclopropyl)phenyl]boronic acid (CAS 2377609-59-9)
- 2-Chloro-3-(2,5-dichlorophenyl)-1-propene (CAS 951892-73-2)
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- 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 13C12 (CAS 109719-81-5)
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- (E)-4-((4-(N-(3,5-dimethylphenyl)sulfamoyl)phenyl)amino)-4-oxobut-2-enoic acid (CAS 468101-36-2)
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- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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