6-(Trifluoromethyl)isoquinoline-1-carboxylic acid CAS 2225878-86-2
| CAS No. | 2225878-86-2 |
| Molecular Formula | C11H6F3NO2 |
| Molecular Weight | 241.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-(Trifluoromethyl)isoquinoline-1-carboxylic acid (CAS 2225878-86-2) is a high-purity analytical reference standard with the molecular formula C11H6F3NO2 and a molecular weight of 241.17 g/mol.
The molecular framework of 6-(Trifluoromethyl)isoquinoline-1-carboxylic acid (C11H6F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures 6-(Trifluoromethyl)isoquinoline-1-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6F3NO2 |
| Molecular Weight | 241.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 8-(Trifluoromethyl)quinoline-2-carboxylic acid (CAS 1023815-99-7)
- 6-(Trifluoromethyl)quinoline-4-carboxylic acid (CAS 1092288-36-2)
- 7-(Trifluoromethyl)quinoline-2-carboxylic acid (CAS 1092304-95-4)
- 1-(3-(Trifluoromethyl)phenyl)-1H-1,2,3-triazole-4-carbaldehyde (CAS 113934-28-4)
- 2-(4-(Trifluoromethyl)phenyl)-2H-1,2,3-triazole-4-carbaldehyde (CAS 1202942-42-4)
- 7-(Trifluoromethyl)isoquinoline-3-carboxylic acid (CAS 1256787-80-0)
- 3-Phenyl-4-(trifluoromethyl)isoxazole-5-carbaldehyde (CAS 1260663-50-0)
- 2-(Trifluoromethyl)quinoline-5-carboxylic acid (CAS 1260671-21-3)
Recommended Standards
- 6-(Trifluoromethoxy)quinoline-2-carbaldehyde (CAS 904369-14-8)
- 6-(Trifluoromethyl)isoquinoline-4-carboxylic acid (CAS 2177266-08-7)
- 6-(Pyridin-4-yl)-4-(trifluoromethyl)pyridazin-3(2H)-one (CAS 866474-39-7)
- 6-(Trifluoromethyl)quinoline-2-carboxylic acid (CAS 849818-58-2)
- N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-2-(2-iodoethoxy)acetamide (CAS 2162120-95-6)
- 3-Ethyl-4-(phenylamino)furan-2(5H)-one (CAS 501653-19-6)
- (R)-3-(3-Methoxyphenoxy)butanoic acid (CAS 1136059-93-2)
- Eperisone impurity 26 (CAS 74532-89-1)
- 1-Benzyl-4-vinyl-1H-pyrazole (CAS 1235542-25-2)
- H-Val-OEt · HCl (CAS 17609-47-1)
- Amlodipine Impurity 60 (CAS 949155-13-9)
- methyl 5-bromo-2H-chromene-8-carboxylate (CAS 1235439-58-3)
- Benzyl 4-bromo-2-fluorobenzoate (CAS 437764-46-0)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com