2-(2,6-Dioxopiperidin-3-yl)-4,5,7-trifluoro-6-hydroxyisoindoline-1,3-dione CAS 2226299-35-8
| CAS No. | 2226299-35-8 |
| Molecular Formula | C13H7F3N2O5 |
| Molecular Weight | 328.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-(2,6-Dioxopiperidin-3-yl)-4,5,7-trifluoro-6-hydroxyisoindoline-1,3-dione (CAS 2226299-35-8), a certified reference material (molecular formula C13H7F3N2O5, MW 328.20 g/mol) for analytical method development and quality control.
The molecular framework of 2-(2,6-Dioxopiperidin-3-yl)-4,5,7-trifluoro-6-hydroxyisoindoline-1,3-dione (C13H7F3N2O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H7F3N2O5 |
| Molecular Weight | 328.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dioxopiperidin Standards
- 3-(2,6-Dioxopiperidin-3-yl)benzo[d]isoxazole-5-sulfonyl chloride (CAS 2623103-51-3)
- 7-(2,6-Dioxopiperidin-3-yl)-4-fluoro-6H-[1,3]dioxolo[4,5-e]isoindole-6,8(7H)-dione (CAS 2667597-93-3)
- 5-(2,6-Dioxopiperidin-1-yl)-2-methoxybenzenesulfonyl chloride (CAS 927999-81-3)
- 3-(2-(2,6-Dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)propanoic acid (CAS 2703770-71-0)
- N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide (CAS 444289-17-2)
- 2-(2,6-Dioxopiperidin-3-yl)-6,7,8,9-tetrahydro-1H-pyrrolo[3,4-h]isoquinoline-1,3(2H)-dione (CAS 2616545-27-6)
- 2-(2,6-Dioxopiperidin-3-yl)-5,7-dihydrocyclopenta[f]isoindole-1,3,6(2H)-trione (CAS 2616551-00-7)
- 4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)butanoic acid (CAS 2413732-05-3)
Recommended Standards
- 1-(Amino(4-bromophenyl)methyl)naphthalen-2-ol (CAS 714953-85-2)
- 2-(3,4-Dichloro-1-methyl-1H-pyrazol-5-yl)-2-methyl-N-(p-tolyl)hydrazine-1-carboxamide (CAS 318284-29-6)
- 1-(Amino(3-bromophenyl)methyl)naphthalen-2-ol (CAS 561052-54-8)
- 2-Nitro-1-(3-nitrophenoxy)-4-(trifluoromethyl)benzene (CAS 500361-94-4)
- 2-Chloro-1-(4-(2-methoxyphenyl)piperazin-1-yl)ethan-1-one (CAS 21057-39-6)
- 5-Amino-1-cyclopentyl-1H-pyrazol-3-ol (CAS 436088-87-8)
- 5-(Dimethoxymethyl)-2,3-dimethoxypyridine (CAS 1138443-97-6)
- Ethyl 3-amino-1,5-dimethyl-1H-pyrrole-2-carboxylate (CAS 83621-89-0)
- 6-Iodo-7-methoxy-2-methylquinazolin-4(1H)-one (CAS 2230840-07-8)
- 11 beta-Hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-en-3-one (CAS 1419705-13-7)
- 4,5-Dichloro-2-methyl-1H-imidazole (CAS 15965-33-0)
- N-((3-Methoxy-4-(oxazol-5-yl)phenyl)carbamothioyl)benzamide (CAS 267647-78-9)
- 6-Chloro-2-propyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine (CAS 1018165-58-6)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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