Benzyl (S)-((3,3-difluoropiperidin-4-yl)methyl)carbamate CAS 2227198-54-9
| CAS No. | 2227198-54-9 |
| Molecular Formula | C14H18F2N2O2 |
| Molecular Weight | 284.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Benzyl (S)-((3,3-difluoropiperidin-4-yl)methyl)carbamate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Benzyl (S)-((3,3-difluoropiperidin-4-yl)methyl)carbamate (CAS 2227198-54-9), molecular formula C14H18F2N2O2 and molecular weight 284.30 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Benzyl (S)-((3,3-difluoropiperidin-4-yl)methyl)carbamate (C14H18F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H18F2N2O2 |
| Molecular Weight | 284.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Benzyl (R)-2-(aminomethyl)-5,5-difluoropiperidine-1-carboxylate (CAS 2306252-94-6)
- Benzyl (S)-2-(aminomethyl)-5,5-difluoropiperidine-1-carboxylate (CAS 2227197-70-6)
- Benzyl (R)-((3,3-difluoropiperidin-4-yl)methyl)carbamate (CAS 2306249-15-8)
- Ethyl 7-(2,3-difluorophenyl)-7-oxoheptanoate (CAS 898753-02-1)
- (S)-1-(4-Chloropyridin-2-yl)ethanamine hydrochloride (CAS 1415257-52-1)
- 2-(2,6-Dioxopiperidin-3-yl)-4-methylisoindoline-1,3-dione (CAS 244057-31-6)
- 1,4-Diethyl 2,2-difluoro-3-methylbutanedioate (CAS 1965305-25-2)
- 1,2,3-trichloro-4-fluorobenzene (CAS 36556-36-2)
- Ethyl 5-amino-3-oxoisoxazole-2(3H)-carboxylate (CAS 1630763-79-9)
- 2-Ethynyl-9H-fluorene (CAS 57700-19-3)
- 1H-Benzo[d]imidazole-1,2-dicarbonitrile (CAS 55810-28-1)
- (1-Methylpiperidin-4-yl)thiourea (CAS 1096840-97-9)
- 3-Fluoro-4-(4-fluorophenoxy)aniline (CAS 937597-91-6)
- (D-Tyr1,N-Me-Phe3)-Neuropeptide FF (H-4752.0001) (CAS 145274-93-7)
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