(5-Chloropyrimidin-2-yl)methanol hydrochloride CAS 2227205-29-8
| CAS No. | 2227205-29-8 |
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 181.02 g/mol gives (5-Chloropyrimidin-2-yl)methanol hydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(5-Chloropyrimidin-2-yl)methanol hydrochloride (CAS 2227205-29-8), molecular formula C5H5ClN2OHCl and molecular weight 181.02 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, (5-Chloropyrimidin-2-yl)methanol hydrochloride (C5H5ClN2OHCl) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 181.02 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (5-Chloropyrimidin-2-yl)methanol hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN2O HCl |
| Molecular Weight | 181.02 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloropyrimidin Standards
- 2-(2-Chloropyrimidin-5-yl)acetonitrile (CAS 1000565-07-0)
- 2-((2-Chloropyrimidin-4-yl)amino)-1-phenylethan-1-ol (CAS 1009330-01-1)
- 1-(6-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazol-5-amine (CAS 1018473-22-7)
- 2-((5-Chloropyrimidin-2-yl)thio)acetic acid (CAS 1023813-98-0)
- (6-chloropyrimidin-4-yl)methanol (CAS 1025351-41-0)
- 4-((6-Chloropyrimidin-4-yl)oxy)aniline (CAS 105130-28-7)
- 2-((6-Chloropyrimidin-4-yl)oxy)quinoxaline (CAS 1065484-81-2)
- 2-((4-Chloropyrimidin-2-yl)oxy)quinoxaline (CAS 1065484-82-3)
Recommended Standards
- 2,3-Dimethylpyrazolo[1,5-a]pyrimidin-7-ol (CAS 1246553-45-6)
- 1-(4-Fluorophenyl)-2-(isopropylthio)-5-phenyl-1H-imidazole (CAS 1206991-32-3)
- Methyl 2-{[(tert-butoxy)carbonyl]amino}-3,3,3-trifluoropropanoate (CAS 1039356-94-9)
- 2,2',5,5'-Tetrabromodiphenyl ether (CAS 446254-24-6)
- Bosentan Impurity 15 (CAS 1257099-43-6)
- Ethyl 6-(4-(diphenylamino)phenyl)-2-oxo-2H-chromene-3-carboxylate (CAS 1056693-13-0)
- 4-(4-Bromophenyl)-2-phenylthiomorpholine-3,5-dione 1,1-dioxide (CAS 339109-46-5)
- n-Methyl-2-(1,3,5-trimethyl-1h-pyrazol-4-yl)ethan-1-amine (CAS 956950-96-2)
- 1-Cyclopentylpiperidin-4-amine hydrochloride (CAS 1000287-02-4)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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