4-Chloro-5-nitro-1H-pyrrolo[2,3-d]pyrimidine CAS 22277-01-6
| CAS No. | 22277-01-6 |
| Molecular Formula | C6H3ClN4O2 |
| Molecular Weight | 198.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 4-Chloro-5-nitro-1H-pyrrolo[2,3-d]pyrimidine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 198.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
4-Chloro-5-nitro-1H-pyrrolo[2,3-d]pyrimidine (CAS 22277-01-6) is a high-purity analytical reference standard with the molecular formula C6H3ClN4O2 and a molecular weight of 198.57 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-Chloro-5-nitro-1H-pyrrolo[2,3-d]pyrimidine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN4O2 |
| Molecular Weight | 198.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 4-Chloro-7-nitro-5H-pyrrolo[3,2-d]pyrimidine (CAS 1260676-83-2)
- 2-Chloro-7H-purine-6-carboxylic acid (CAS 1267954-74-4)
- 4-Chloro-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole (CAS 128694-69-9)
- 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine (CAS 1363380-51-1)
- 4-Chloro-5-nitro-1H-pyrazolo[3,4-b]pyridine (CAS 1638769-09-1)
- 6-Chloro-3-nitro-imidazo[1,2-b]pyridazine (CAS 18087-76-8)
- 8-Chloro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid (CAS 1935512-03-0)
- 4-Chloro-3-ethyl-5-(trifluoromethyl)-1H-Pyrazole (CAS 637022-66-3)
Recommended Standards
- 5-Oxo-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonyl chloride (CAS 86070-23-7)
- 4-Amino-6-chloro-3-nitropicolinonitrile (CAS 944388-71-0)
- 6-Chloro-[1,2,4]triazolo[1,5-b]pyridazine-2-carboxylic acid (CAS 215530-62-4)
- 4-(Chloromethyl)-1-(2,2,2-trifluoroethyl)-1h-pyrazole (CAS 405103-71-1)
- 2-(6-Chloro-3-pyridyl)-5-[5-(trifluoromethyl)-2-pyridyl]-1,3,4-oxadiazole (CAS 265307-78-6)
- 3,4-Di-O-benzyl DL-threo-Droxidopa Hydrochloride (CAS 73594-43-1)
- 2,2,3,3,4,4,4-Heptafluorobutyl (2,2,3,4,4,4-hexafluorobutyl) carbonate (CAS 1980048-57-4)
- 6-Hydroxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbonitrile (CAS 178374-34-0)
- 2-([1,1'-biphenyl]-4-yl)-N-methylethan-1-amine (CAS 669015-06-9)
- 2-(2-Pyridyl)-2-propanol (CAS 37988-38-8)
- 2-Chloro-N-methyl-N-(2-oxo-2-(pyrazin-2-yl)ethyl)acetamide (CAS 1353981-03-9)
- tert-Butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (CAS 570409-62-0)
- 6-Fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 420830-23-5)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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