3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine CAS 2228547-21-3

Purity 97%+In StockPharmaceutical Standards
CAS No.2228547-21-3
Molecular FormulaC10H9ClF3NO
Molecular Weight251.63 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine CAS 2228547-21-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 251.63 g/mol gives 3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine (CAS 2228547-21-3), molecular formula C10H9ClF3NO and molecular weight 251.63 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine (C10H9ClF3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-(4-Chloro-3-(trifluoromethyl)phenoxy)azetidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H9ClF3NO
Molecular Weight251.63 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1998
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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