2-Ethynyl-1,3-difluoro-4-nitrobenzene CAS 2229517-52-4
| CAS No. | 2229517-52-4 |
| Molecular Formula | C8H3F2NO2 |
| Molecular Weight | 183.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 2-Ethynyl-1,3-difluoro-4-nitrobenzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
2-Ethynyl-1,3-difluoro-4-nitrobenzene (CAS 2229517-52-4) is a high-purity analytical reference standard with the molecular formula C8H3F2NO2 and a molecular weight of 183.11 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-Ethynyl-1,3-difluoro-4-nitrobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 183.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H3F2NO2 |
| Molecular Weight | 183.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethynyl Standards
- 1-Ethynyl-2,5-difluoro-4-nitrobenzene (CAS 2229084-84-6)
- 1-Ethynyl-4,5-difluoro-2-nitrobenzene (CAS 2228588-47-2)
- 5-Ethynyl-6-methoxyquinoline (CAS 1420790-19-7)
- 2-Ethynyl-7-methoxynaphthalene (CAS 144269-93-2)
- 6-Ethynyl-N-methylquinolin-2-amine (CAS 1956354-68-9)
- 1-Benzyl-4-ethynyl-1H-pyrazole (CAS 905751-62-4)
- 1-Ethynyl-2-methoxynaphthalene (CAS 917894-85-0)
- 1-Ethynyl-4-methoxynaphthalene (CAS 61639-32-5)
Recommended Standards
- 2,6-DifluorobenzoylisocyanateDiscontinued (CAS 60731-73-9)
- 4,7-Difluoroisatin (CAS 749240-52-6)
- 4-Cyano-2,5-difluorobenzoic acid (CAS 198280-48-7)
- 5,6-Difluorobenzo[d]oxazole-2-carbaldehyde (CAS 944898-88-8)
- 1-Benzyl-1H-indazole-3-carbaldehyde (CAS 1186509-61-4)
- 4',4''',4''''',4'''''''-(Ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-3-carbaldehyde)) (CAS 2351847-81-7)
- N-(2-aminoethyl)-1-methyl-1H-pyrazol-3-amine dihydrochloride (CAS 1803587-64-5)
- Ethyl 3-bromo-1-(3-chloropyridin-2-yl)-4,5-dihydro-1H-pyrazole-5-carboxylate (CAS 500011-91-6)
- 2-(Cyclobutanecarboxamidomethyl)thiazole-4-carboxylic acid (CAS 1501578-26-2)
- 2-[(3-methoxyphenyl)methoxy]propanoic acid (CAS 1016890-44-0)
- 6-Butyl-1,2,3,4-tetrahydronaphthalene (CAS 30654-45-6)
- Bilastine impurity 96 (CAS CATO-C4X-225396)
- Piribedil Impurity 2 (CAS CATO-C4X-28132)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com