3,3-Bis(fluoromethyl)cyclobutane-1-carboxylic acid CAS 2231675-46-8
| CAS No. | 2231675-46-8 |
| Molecular Formula | C7H10F2O2 |
| Molecular Weight | 164.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3,3-Bis(fluoromethyl)cyclobutane-1-carboxylic acid (CAS 2231675-46-8) is a high-purity analytical reference standard with the molecular formula C7H10F2O2 and a molecular weight of 164.15 g/mol.
The molecular framework of 3,3-Bis(fluoromethyl)cyclobutane-1-carboxylic acid (C7H10F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H10F2O2 |
| Molecular Weight | 164.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
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Recommended Standards
- 3-(Difluoromethoxy)cyclohexan-1-one (CAS 2285099-77-4)
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- 2,6-Difluoronaphthalene (CAS 59079-69-5)
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- 2,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene (CAS 853377-10-3)
- Methyl 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}-1-oxo-1,2-dihydroisoquinoline-4-carboxylate (CAS 339106-16-0)
- Sodium orthosilicate (CAS 13472-30-5)
- 2-(Azetidin-3-yloxy)ethan-1-ol (CAS 1428757-87-2)
- 4-Chloro-2-(thiophen-2-yl)benzofuro[3,2-d]pyrimidine (CAS 1706442-99-0)
- (R)-Tamsulosin Hydrochloride-D4 (CAS 2518100-55-3)
- 2-((5,7-Diiodoquinolin-8-yl)oxy)-N-hydroxyacetimidamide (CAS 88757-77-1)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
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