Bazedoxifene Acetate Impurity 2 CAS 223251-25-0
| CAS No. | 223251-25-0 |
| Molecular Formula | C15H22ClNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C15H22ClNOHCl, Bazedoxifene Acetate Impurity 2 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 304.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Bazedoxifene Acetate Impurity 2 (CAS 223251-25-0, C15H22ClNOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H22ClNO HCl |
| Molecular Weight | 304.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bazedoxifene Standards
- Bazedoxifene Acetate Impurity 9 (CAS 104599-10-2)
- Bazedoxifene-D4 (CAS 1133695-49-4)
- Bazedoxifene N-Oxide (CAS 1174289-22-5)
- Bazedoxifene-d4 N-Oxide (CAS 1794810-68-6)
- Bazedoxifene-d4 Acetate (CAS 1795027-71-2)
- Bazedoxifene Acetate Impurity 8 (CAS 1802552-31-3)
- Bazedoxifene Acetate Impurity 14 (CAS 198479-63-9)
- Bazedoxifene Acetate Impurity 7 (CAS 198480-21-6)
Recommended Standards
- Sunitinib Impurity 51 (CAS 253870-02-9)
- Tipiracil Impurity 4 (CAS CATO-C4X-10054)
- Lovastatin Impurity 25 (CAS CATO-C4X-168425)
- Anlotinib Impurity 4 (CAS CATO-C4X-32834)
- tert-Butyl 3-hydroxy-4,5-dimethoxybenzoate (CAS 2724938-71-8)
- 3-(aminomethyl)bicyclo[1.1.1]pentan-1-ol hydrochloride (CAS 2227206-71-3)
- 8'-Chloro-7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] hydrochloride (CAS 1251950-63-6)
- β-Aminotetrahydro-3-furanpropanol (CAS 1315059-90-5)
- 1-{[(3,4-dichlorophenyl)methyl]amino}propan-2-ol (CAS 856977-77-0)
- Palmitoyl Tripeptide-5 TFA (CAS 623172-55-4（free base）)
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