1-Chloro-4-hydroxy-7-methoxyisoquinoline-3-carboxylic acid CAS 223388-01-0
| CAS No. | 223388-01-0 |
| Molecular Formula | C11H8ClNO4 |
| Molecular Weight | 253.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1-Chloro-4-hydroxy-7-methoxyisoquinoline-3-carboxylic acid (CAS 223388-01-0), a certified reference material (molecular formula C11H8ClNO4, MW 253.64 g/mol) for analytical method development and quality control.
Structurally, 1-Chloro-4-hydroxy-7-methoxyisoquinoline-3-carboxylic acid (C11H8ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 253.64 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-Chloro-4-hydroxy-7-methoxyisoquinoline-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8ClNO4 |
| Molecular Weight | 253.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2020 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 8-Chloro-4-hydroxy-7-methoxyquinoline-2-carboxylic acid (CAS 1001095-54-0)
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- 5-Chloro-2-methoxy-4-(prop-2-ynamido)benzoic acid (CAS 1156747-97-5)
- 6-chloro-4-hydroxy-8-methoxyquinoline-3-carboxylic acid (CAS 1189106-26-0)
- 1-(3-Chloro-4-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1267684-30-9)
- 3-chloro-2-fluoro-5-sulfamoylbenzoic acid (CAS 1423025-14-2)
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Recommended Standards
- 1-{[(4-Chlorophenyl)carbonyl]oxy}pyrrolidine-2,5-dione (CAS 68388-09-0)
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- (5-(4-Chloro-3-nitrophenyl)furan-2-yl)methanol (CAS 677304-92-6)
- 2-(4-Chloro-2-(isoxazol-5-yl)phenoxy)acetic Acid (CAS 882689-21-6)
- (3,3,3-Trifluoropropyl)trimethoxysilane 3,3,3-(trifluoropropyl)trimethoxysilane 3,3,3-trifluoropropyltrimethoxysilane 429-60-7 trimethoxy(3,3,3-trifluoropropyl)silane (CAS 429-60-7)
- 3-Ethoxy-4-fluoro-5-methylbenzaldehyde (CAS 2385710-59-6)
- (6-Ethoxy-4-methylpyridin-3-yl)boronic acid (CAS 1256355-37-9)
- 6-Fluoro-2-hydrazinylpyrimidin-4-amine (CAS 188987-87-3)
- N,N'-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine-2,6-diyl)bis(2-phenoxyacetamide) (CAS 156549-47-2)
- Isoxazole-3,5-dicarboxylicacid (CAS 89379-30-6)
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- Methyl (2S,4S)-4-[3-(acetylamino)phenoxy]-2-pyrrolidinecarboxylate hydrochloride (CAS 1354484-58-4)
- Phorbol (CAS 17673-25-5)
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