3-Chloro-5-nitropyridine CAS 22353-33-9
| CAS No. | 22353-33-9 |
| Molecular Formula | C5H3ClN2O2 |
| Molecular Weight | 158.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-5-nitropyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-Chloro-5-nitropyridine (CAS 22353-33-9) is a high-purity analytical reference standard with the molecular formula C5H3ClN2O2 and a molecular weight of 158.54 g/mol.
Based on its molecular formula C5H3ClN2O2, 3-Chloro-5-nitropyridine contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 158.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C5H3ClN2O2 |
| Molecular Weight | 158.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-6-hydroxypyrimidine-5-carbaldehyde (CAS 1627504-57-7)
- 2-Chloro-5-hydroxycyclohexa-2,5-diene-1,4-dione (CAS 89284-69-5)
- 2-Chloro-6-Nitropyridine (CAS 94166-64-0)
- 3-Chloro-2-nitropyridine (CAS 54231-32-2)
- 4-Chloro-2-nitropyridine (CAS 65370-42-5)
- 4-Chloro-2-pyrimidinecarboxylic Acid (CAS 944901-20-6)
- 5-Chloro-2-nitropyridine (CAS 52092-47-4)
- 2-Chloro-5-nitropyridine (CAS 4548-45-2)
Recommended Standards
- 3-chloropyrazine-2-carboxylic acid (CAS 27398-39-6)
- 2-Oxo-2H-pyran-5-carbonyl chloride (CAS 23090-18-8)
- 3-Hydroxypyrazine-2-carbonyl chloride (CAS 98136-34-6)
- 2-Chloropyrimidine-5-carboxylic Acid (CAS 374068-01-6)
- N-(Benzo[d]thiazol-2-yl)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide (CAS 775316-95-5)
- 5-Chloro-3-(2-fluoro-phenyl)-[1,2,4]thiadiazole (CAS 138426-25-2)
- 3-Oxaspiro[5.5]undecane-8,10-dione (CAS 1058731-65-9)
- Lumisterol Impurity 2 (CAS 516-79-0)
- tert-Butyl (R)-(5-(1-aminoethyl)-4-methylthiazol-2-yl)carbamate (CAS 2227739-97-9)
- H-Gly-Pro-βNA (CAS 16046-01-8)
- 5-Formyl-2-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]oxazole-7-carbonitrile (CAS 2231027-08-8)
- 3,4-Diaminobenzoic acid hydrochloride (CAS 1571-68-2)
- 3-Chloro-4,5-diiodo-6-methoxypyridazine (CAS 1375303-14-2)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
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