N-acetoxy-N-acetylpropionamide CAS 22427-07-2
| CAS No. | 22427-07-2 |
| Molecular Formula | C10H9F3O |
| Molecular Weight | 202.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-acetoxy-N-acetylpropionamide.
N-acetoxy-N-acetylpropionamide (CAS 22427-07-2) is a high-purity analytical reference standard with the molecular formula C10H9F3O and a molecular weight of 202.17 g/mol.
Structurally, N-acetoxy-N-acetylpropionamide (C10H9F3O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 202.17 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O |
| Molecular Weight | 202.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
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Recommended Standards
- Fenfluramine Impurity 4 (CAS 21906-39-8)
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- Cybutryne Metabolite M1 (CAS 30125-65-6)
- Ethyl 2-(5-chloro-2-methyl-1H-indol-3-yl)acetate (CAS 3446-72-8)
- 2-(Benzyloxy)-6-chloropyridine-4-sulfonyl chloride (CAS 1393559-92-6)
- 1-(Tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (CAS 2306260-70-6)
- Diethyl 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3,5-dicarboxylate (CAS 937601-37-1)
- (3-(Aminomethyl)pyrrolidin-1-yl)(2-bromo-5-fluorophenyl)methanone (CAS 1838921-36-0)
- Methyl 4-(3-bromophenyl)-1-methylpyrrolidine-3-carboxylate (CAS 1706448-91-0)
- n-Ethyl-N-(morpholin-2-ylmethyl)pyridazin-3-amine (CAS 1423035-12-4)
- 2,5-Dinitroaniline (CAS 619-18-1)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
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