N-(4-chlorophenyl)-2-hydroxy-4-oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide CAS 224313-84-2
| CAS No. | 224313-84-2 |
| Molecular Formula | C17H10ClN3O3S |
| Molecular Weight | 371.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-chlorophenyl)-2-hydroxy-4-oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide.
N-(4-chlorophenyl)-2-hydroxy-4-oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide (CAS 224313-84-2) is a high-purity analytical reference standard with the molecular formula C17H10ClN3O3S and a molecular weight of 371.80 g/mol.
The molecular framework of N-(4-chlorophenyl)-2-hydroxy-4-oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide (C17H10ClN3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H10ClN3O3S |
| Molecular Weight | 371.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related N Standards
- 1119391-59-1 3-(4-chlorophenyl)-4-imino-6-(thiophen-2-yl)-1H,2H,3H,4H,7H,8H-[1,3]diazino[5,4-d]pyrimidine-2,8-dione MS-10940 (CAS 1119391-59-1)
- 3-[(4-Chlorophenyl)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one (CAS 866042-14-0)
- N-(4-Chlorophenyl)-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfanyl]benzamide (CAS 339020-03-0)
- 3-(4-Chlorophenyl)-9-(3-hydroxypropyl)-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one (CAS 1010933-62-6)
- 2-(2-((4-Chlorophenyl)thio)acetyl)-N-(2,4-difluorophenyl)hydrazine-1-carboxamide (CAS 329699-89-0)
- N-(2-(3-(4-Chlorophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)-2-fluorobenzamide (CAS 921851-57-2)
- (4Z)-1-(4-Chlorophenyl)-3-ethoxy-4-{[(4-methoxyphenyl)amino]methylidene}-4,5-dihydro-1H-pyrazol-5-one (CAS 338751-08-9)
- 1-(4-Chlorophenyl)-2-phenylimidazo[2,1-b]quinazolin-5(1H)-one (CAS 62481-21-4)
Recommended Standards
- Avanafil Impurity 56 (CAS 2310299-29-5)
- 4-Amino-3-(4-chlorophenyl)-6-(thiophen-3-yl)-3,7-dihydropyrimido[5,4-d]pyrimidine-2,8-dione (CAS 634155-03-6)
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-chloro-4-methoxyphenoxy)-2-pyrrolidinecarboxylic acid (CAS 1354486-68-2)
- 3-(5-Chloro-2-(methylthio)pyrimidin-4-yl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2-yl)propanenitrile (CAS 328033-13-2)
- 2-(3,4-Dichlorophenyl)-2-(dimethylamino)-acetonitrile (CAS 15189-92-1)
- 2-Pyrrolidinecarbonitrile Hydrochloride (CAS 1199773-80-2)
- (E)-3-(4-fluoro-3-methylphenyl)acrylic acid (CAS 913699-82-8)
- Ethyl 2-(2-((3-methyl-4-oxo-7-phenyl-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamido)benzoate (CAS 1040633-46-2)
- 2-Benzhydrylpyridine (CAS 3678-70-4)
- N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-1-methyl-1H-pyrazole-3-carboxamide (CAS 1170780-96-7)
- tert-Butyl 7-(2-methoxy-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate (CAS 925889-81-2)
- 1-[4-(chloromethyl)phenyl]-1h-pyrazole hydrochloride (CAS 1052543-40-4)
- 4-((Cyclopropylamino)methyl)-2-fluorophenol (CAS 1537583-94-0)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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