Fluoxetine Impurity 29 CAS 2243504-22-3
| CAS No. | 2243504-22-3 |
| Molecular Formula | C18H20F3NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fluoxetine Impurity 29.
Fluoxetine Impurity 29 (CAS 2243504-22-3) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20F3NOHCl and a molecular weight of 359.82 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Fluoxetine Impurity 29 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 359.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20F3NO HCl |
| Molecular Weight | 359.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Fluoxetine Standards
- Fluoxetine Impurity 37 (CAS 101-98-4)
- Fluoxetine Impurity 44 (CAS 101-98-4（free base）)
- Fluoxetine Impurity 19 (CAS 1026723-45-4)
- Fluoxetine Impurity 26 (CAS 103756-12-3)
- (S)-Fluoxetine Hydrochloride (CAS 114247-06-2)
- (R)-Fluoxetine Hydrochloride (CAS 114247-09-5)
- Fluoxetine oxalate, >98% (CAS 114414-02-7)
- Fluoxetine-d5 HCl (CAS 1173020-43-3)
Recommended Standards
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- 4-Fluoro-3-(3-methylphenyl)propiophenone (CAS 56201-97-9)
- Beclometasone Dipropionate Monohydrate EP Impurity U (CAS 79578-39-5)
- 4-Fluoro-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid (CAS 1190309-85-3)
- n-(4-Amino-3-bromophenyl)acetamide (CAS 860745-87-5)
- 3,5,5-Trimethyl-1-(piperazin-1-yl)hexan-1-one (CAS 1094220-86-6)
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