3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol CAS 2244893-49-8
| CAS No. | 2244893-49-8 |
| Molecular Formula | C12H15BF2O3 |
| Molecular Weight | 256.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol.
3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 2244893-49-8), molecular formula C12H15BF2O3 and molecular weight 256.05 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (C12H15BF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.5, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 256.05 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15BF2O3 |
| Molecular Weight | 256.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 97% (CAS 1029439-83-5)
- 2,3-Difluoro-4-hydroxyphenylboronic Acid Pinacol Ester (CAS 1029439-85-7)
- 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1029439-87-9)
- 2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1220219-43-1)
- 2,4-Difluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1451391-16-4)
- 2,3-Difluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1631756-19-8)
- 2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1817835-85-0)
- (7,8-Difluoro-2-propylchroman-6-yl)boronic acid (CAS 819861-92-2)
Recommended Standards
- 2,6-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 2756163-62-7)
- 3-Amino-6-bromobenzofuran-2-carboxylic acid (CAS 887246-19-7)
- 2-(Benzo[d]isoxazol-3-yl)-2-bromoacetic acid (CAS 37924-67-7)
- 4-(Cyclopentyloxy)-3,5-difluoro-2-methylphenylboronic acid (CAS 2096336-27-3)
- tert-Butyl (2-amino-4,6-difluorophenyl)carbamate (CAS 1501143-11-8)
- N-(cyclohexylmethyl)cyclobutanamine (CAS 1247428-90-5)
- (3-Chloro-5-(trifluoromethyl)pyridin-2-yl)difluoromethyl trifluoromethanesulfonate (CAS 1823188-15-3)
- 1-Isothiocyanato-8-(methylsulfinyl)octane (CAS 75272-81-0)
- 4-Hydroxybenzylamine Hydrate (CAS 2006278-39-1)
- 4-Isopropyl-1-(p-tolyl)-1,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione (CAS 2097935-75-4)
- 5-Fluoro-2-(2-(pyrrolidin-1-yl)ethoxy)aniline (CAS 937596-81-1)
- 2-Bromo-2,3,3,3-tetrafluoropropanoyl bromide (CAS 41874-81-1)
- 3-(4-phenoxyphenyl)-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 438029-86-8)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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