Vardenafil Impurity 52 CAS 224789-22-4
| CAS No. | 224789-22-4 |
| Molecular Formula | C18H22N4O2 |
| Molecular Weight | 326.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Vardenafil Impurity 52 (CAS 224789-22-4, C18H22N4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vardenafil Impurity 52 (C18H22N4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Vardenafil Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22N4O2 |
| Molecular Weight | 326.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Nitrogen Atoms | 4 |
Related Vardenafil Standards
- Vardenafil Impurity 21 (CAS 927690-90-2)
- Vardenafil Impurity 47 (CAS 910554-78-8)
- Vardenafil Impurity 51 (CAS CATO-C4X-101751)
- Vardenafil Impurity 21 (Mixture of E/Z-Isomers) (CAS 68282-25-7)
- Vardenafil Impurity 46 (CAS 1417529-59-9)
- Vardenafil Impurity 24 (CAS 910554-77-7)
- Vardenafil Impurity 55 (CAS 2520113-41-9)
- Vardenafil Impurity 8 (CAS 224789-20-2)
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