3-Amino-3-(3,5-dimethyl-1H-pyrazol-4-yl)acrylonitrile CAS 225220-78-0
| CAS No. | 225220-78-0 |
| Molecular Formula | C8H10N4 |
| Molecular Weight | 162.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Amino-3-(3,5-dimethyl-1H-pyrazol-4-yl)acrylonitrile (CAS 225220-78-0), molecular formula C8H10N4 and molecular weight 162.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Amino-3-(3,5-dimethyl-1H-pyrazol-4-yl)acrylonitrile (C8H10N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 3-Amino-3-(3,5-dimethyl-1H-pyrazol-4-yl)acrylonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10N4 |
| Molecular Weight | 162.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 2-(4-Amino-3-methylphenoxy)acetonitrile (CAS 1016724-90-5)
- 2-Amino-7,8-dihydroquinolin-5(6H)-one (CAS 1082192-52-6)
- 5-Amino-1-cyclobutyl-1h-pyrazole-4-carbonitrile (CAS 1082745-58-1)
- 6-Amino-3-methylindolin-2-one (CAS 108533-35-3)
- 6-Amino-2,3-dihydroquinolin-4(1h)-one (CAS 1086397-91-2)
- 3-Amino-7-methyl-1,3-dihydro-2H-indol-2-one (CAS 1103265-45-7)
- 3-Amino-5-methylindolin-2-one (CAS 1104746-13-5)
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Recommended Standards
- 3-Amino-1-phenylazetidin-2-one (CAS 889359-59-5)
- 3-Amino-3,4-dihydroquinolin-2(1H)-one (CAS 40615-17-6)
- 3-Amino-1H-indazole-5-methanamine (CAS 267876-23-3)
- 3-Amino-4-ethoxybenzonitrile (CAS 72635-79-1)
- 5-(Furan-2-yl)-5-methyldihydrofuran-2(3H)-one (CAS 185700-56-5)
- 2-(1H-imidazol-2-yl)-2-phenylethan-1-amine dihydrochloride (CAS 1803605-54-0)
- 3-(Trifluoroacetamido)propanoic acid (CAS 50632-82-1)
- 0520AD 1185303-89-2 3-[(2-Bromo-4-methylphenoxy)methyl]piperidine hydrochloride C13H19BrClNO (CAS 1185303-89-2)
- 375-84-8 Tridecafluoroheptanoyl fluoride Heptanoyl fluoride, 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoro- Heptanoyl fluoride, tridecafluoro- EINECS 206-797-3 (CAS 375-84-8)
- Vildagliptin Impurity 68 (CAS CATO-C4X-110068)
- 4-Nitro-1H-indole-3-carbonitrile (CAS 4770-00-7)
- Propanethiohydrazide (CAS 89946-93-0)
- n-Methyl-1-(5-methyl-4-phenyl-4h-1,2,4-triazol-3-yl)methanamine (CAS 1249003-45-9)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
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