5-(Difluoromethyl)-1,2,3,4-tetrahydro-1,6-naphthyridine CAS 2254053-80-8
| CAS No. | 2254053-80-8 |
| Molecular Formula | C9H10F2N2 |
| Molecular Weight | 184.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(Difluoromethyl)-1,2,3,4-tetrahydro-1,6-naphthyridine (CAS 2254053-80-8) is a high-purity analytical reference standard with the molecular formula C9H10F2N2 and a molecular weight of 184.19 g/mol.
5-(Difluoromethyl)-1,2,3,4-tetrahydro-1,6-naphthyridine (C9H10F2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Difluoromethyl)-1,2,3,4-tetrahydro-1,6-naphthyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10F2N2 |
| Molecular Weight | 184.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- tert-Butyl (2-chloro-5-fluoropyrimidin-4-yl)carbamate (CAS 731817-75-7)
- 5-Propylpyrimidine-2-thiol (CAS 52767-84-7)
- 2-Chloro-3-isobutylpyrazine (CAS 57674-17-6)
- 6-(Chloromethyl)pteridine-2,4-diamine (CAS 57521-63-8)
- 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-sulfonamide (CAS 5338-86-3)
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