Acebutolol EP Impurity B CAS 22568-64-5
| CAS No. | 22568-64-5 |
| Molecular Formula | C16H24N2O4 |
| Molecular Weight | 308.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Acebutolol EP Impurity B (CAS 22568-64-5) is a certified pharmaceutical impurity reference standard with the molecular formula C16H24N2O4 and a molecular weight of 308.37 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Acebutolol EP Impurity B is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 308.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H24N2O4 |
| Molecular Weight | 308.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 2 |
Related Acebutolol Standards
- Acebutolol EP Impurity F (CAS 96480-91-0)
- Acebutolol Hydrochloride - Impurity E (Freebase) (CAS 27783-53-5)
- Acebutolol EP Impurity I (CAS 441019-91-6)
- Acebutolol EP Impurity J (CAS 28197-36-6)
- R-Acebutolol (CAS 68107-81-3)
- S-Acebutolol (CAS 68107-82-4)
- Acebutolol EP Impurity A (CAS 28197-66-2)
- Acebutolol-d5 (CAS 1189500-68-2)
Recommended Standards
- 8-Hydroxycarteolol (CAS 59826-22-1)
- Aminooxy-PEG3-C2-NH-Boc (CAS 2062663-65-2)
- 7,7-Dioxido-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl benzoate (CAS 338776-89-9)
- Carbamic acid, [2-[(6-hydroxyhexyl)amino]-2-oxoethyl]-, phenylmethyl ester (9CI) (CAS 75937-30-3)
- Arotinolol Impurity 36 (CAS 52561-15-6)
- N-Nitroso Vortioxetine Bromo Impurity 106 (CAS CATO-C4X-1056106)
- Bisoprolol Impurity 58 (CAS CATO-C4X-124758)
- Sulfasalazine Impurity 2 (RRT 0.75) (CAS 139-56-0)
- 3-Phenyl-4,5-dihydro-1H-pyrazole-5-carboxylic acid (CAS 67718-46-1)
- 2-(4-(4-Iodophenoxy)-1H-pyrazol-1-yl)ethanol (CAS 1707734-83-5)
- 1,8-Bis(diphenylphosphino)octane (CAS 41625-30-3)
- butyl 1-chloroethyl carbonate (CAS 91508-03-1)
- 3-(chloromethyl)-1-(4-chlorophenyl)-1H-pyrazole (CAS 1481659-08-8)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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