3-(Difluoromethyl)isothiazol-5-amine CAS 2270872-91-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Difluoromethyl)isothiazol-5-amine.

3-(Difluoromethyl)isothiazol-5-amine (CAS 2270872-91-6), molecular formula C4H4F2N2S and molecular weight 150.15 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 3-(Difluoromethyl)isothiazol-5-amine (C4H4F2N2S) contains a nitrile group, sulfur-containing functionality, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 150.15 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-(Difluoromethyl)isothiazol-5-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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