2-Bromo-5-chlorobenzo[b]thiophene CAS 227802-38-2
| CAS No. | 227802-38-2 |
| Molecular Formula | C8H4BrClS |
| Molecular Weight | 247.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Bromo-5-chlorobenzo[b]thiophene (CAS 227802-38-2), molecular formula C8H4BrClS and molecular weight 247.54 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Bromo-5-chlorobenzo[b]thiophene (C8H4BrClS) is characterized by sulfur-containing functionality, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrClS |
| Molecular Weight | 247.54 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | Cl/Br-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 1-(Imidazo[1,2-a]pyridin-3-yl)ethanamine dihydrochloride (CAS 1951444-31-7)
- 3-Bromo-4,6-difluoro-2-nitrophenol (CAS 2852767-54-3)
- 2-chloro-5-(chloromethyl)pyrazine (CAS 105985-21-5)
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