Tert-butyl ((3R,4S)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate CAS 2278296-49-2
| CAS No. | 2278296-49-2 |
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tert-butyl ((3R,4S)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate (C10H18F2N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Tert-butyl ((3R,4S)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate (CAS 2278296-49-2), a certified reference material (molecular formula C10H18F2N2O2, MW 236.26 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Tert-butyl ((3R,4S)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Tert-butyl ((3R,4R)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate (CAS 862107-96-8)
- Tert-butyl ((3S,4S)-4-(difluoromethyl)pyrrolidin-3-yl)carbamate (CAS 862107-95-7)
- Tert-butyl ((3,3-difluoropyrrolidin-2-yl)methyl)carbamate (CAS 2306272-62-6)
- tert-Butyl (3R)-3-amino-4,4-difluoropiperidine-1-carboxylate (CAS 2091351-96-9)
- 1-(3,5-Dimethylbenzyl)cyclopropan-1-amine (CAS 869535-70-6)
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Why CATO?
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