1-(Methoxymethyl)-2-(trifluoromethyl)benzene CAS 227948-39-2
| CAS No. | 227948-39-2 |
| Molecular Formula | C9H9F3O |
| Molecular Weight | 190.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(Methoxymethyl)-2-(trifluoromethyl)benzene (CAS 227948-39-2), molecular formula C9H9F3O and molecular weight 190.16 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 1-(Methoxymethyl)-2-(trifluoromethyl)benzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9F3O |
| Molecular Weight | 190.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | F-containing |
Related Methoxymethyl Standards
- 1-(Methoxymethyl)-4-(trifluoromethyl)benzene (CAS 155820-05-6)
- 1-(Methoxymethyl)-3-(trifluoromethyl)benzene (CAS 380633-51-2)
- 1-(Methoxymethyl)-1H-benzo[d]imidazole-2-carbaldehyde (CAS 118468-97-6)
- 2-[3-(methoxymethyl)-1H-1,2,4-triazol-5-yl]pyridine (CAS 1216265-72-3)
- 2-(Methoxymethyl)-5,6-dimethyl-1H-1,3-benzodiazole (CAS 1176128-05-4)
- 3-[2-(methoxymethyl)phenyl]-2-methylprop-2-enal (CAS 1563755-20-3)
- 4-(3-(Methoxymethyl)phenyl)but-3-en-2-one (CAS 95068-27-2)
- 4-(4-(Methoxymethyl)phenyl)but-3-en-2-one (CAS 95068-13-6)
Recommended Standards
- 1-(Difluoromethyl)-4-ethoxy-2-fluorobenzene (CAS 2149591-21-7)
- 1-(Bicyclo[2.2.1]Hept-5-En-2-Yl)-2,2,2-Trifluoroethanone (CAS 484649-07-2)
- 1-(Pyridin-2-yl)-1H-1,2,4-triazole-3-carboxylic acid (CAS 90220-88-5)
- 1-(Bicyclo[2.2.1]Hept-2-En-1-Yl)-2,2,2-Trifluoroethanone (CAS 424826-62-0)
- 2-Bromo-5-chloro-4-trifluoromethyl-pyridine (CAS 1188476-72-3)
- (2E)-N-(4-Methoxyphenyl)-2-{[(4-methoxyphenyl)amino]methylidene}-3-oxobutanamide (CAS 97077-98-0)
- Boc-L-cyclobutylglycine (CAS 155905-77-4)
- 4-Bromo-2-trifluoromethylphenyl isothiocyanate (CAS 206559-46-8)
- 5-Bromo-1-methyl-3,4-dihydroquinazolin-2(1h)-one (CAS 1934599-61-7)
- 5-Fluoro-2-(phenylsulfonyl)-1H-indole (CAS 1555519-77-1)
- Diethyl (4-methoxyphenyl)phosphonate (CAS 3762-33-2)
- 2,8-Dimethoxyquinazoline-6-carboxylic acid (CAS 2721375-00-2)
- Ethyl 4-(3-Methoxyphenyl)thiazole-2-carboxylate (CAS 886366-81-0)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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