Rivaroxaban Impurity 128 CAS 2304798-51-2
| CAS No. | 2304798-51-2 |
| Molecular Formula | C19H20ClN3O6S |
| Molecular Weight | 453.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rivaroxaban Impurity 128 (CAS 2304798-51-2, C19H20ClN3O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rivaroxaban Impurity 128 (C19H20ClN3O6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 453.90 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rivaroxaban Impurity 128 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H20ClN3O6S |
| Molecular Weight | 453.90 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Open Oxomorpholine Ring (CAS 1160170-00-2)
- Rivaroxaban Impurity 209 (CAS CATO-C4X-1090209)
- Rivaroxaban Impurity 206 (CAS CATO-C4X-1090206)
- Rivaroxaban Impurity 28 (CAS 2206360-74-7)
- Rivaroxaban Impurity 88 (CAS CATO-C4X-109088)
- Rivaroxaban 3-Hydroxy Metabolite (CAS 1159977-46-4)
- Rivaroxaban Impurity 15 (Mixture of Diastereomers) (CAS 1160169-99-2)
- Rivaroxaban 4-Hydroxy Metabolite (CAS 1161719-51-2)
Recommended Standards
- PF-06672131 (CAS 1621002-27-4)
- N-Fmoc-L-HomoPhe(3-Cl，4-F)-OH (CAS 2350248-70-1)
- N-Fmoc-L-HomoPhe(3-Cl ,5-F)-OH (CAS 2350335-79-2)
- Cloxacillin EP Impurity A (CAS 1642629-96-6)
- Ascorbic Acid Impurity 39 (CAS 492-30-8)
- Canagliflozin impurity 115 (CAS CATO-C4X-1123115)
- Ozenoxacin Impurity 85 (CAS CATO-C4X-279685)
- (S)-TERT-BUTYL (4-FLUORO-1-HYDROXY-4-METHYLPENTAN-2-YL)CARBAMATE (CAS 857026-02-9)
- 2,2,2-Trifluoroethyl n-(3,5-dimethyl-1h-pyrazol-4-yl)carbamate (CAS 1187446-51-0)
- 2-Heptyl-4-methyl-1,3-dioxolane (CAS 74094-61-4)
- (3aR,5R,6S,6aR)-5-(((tert-Butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (CAS 114861-14-2)
- trans-2-(3-Fluorobenzoyl)cyclohexane-1-carboxylic acid (CAS 733742-79-5)
- 5-Chloro-6-(trifluoromethyl)-2-pyridinecarboxylic Acid (CAS 749875-06-7)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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