Varenicline Impurity 45 CAS 230615-05-1
| CAS No. | 230615-05-1 |
| Molecular Formula | C11H14N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Varenicline Impurity 45 (CAS 230615-05-1, C11H14N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Varenicline Impurity 45 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 210.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14N2 HCl |
| Molecular Weight | 210.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Varenicline Standards
- Varenicline Impurity 28 (CAS 1026685-55-1)
- Varenicline Impurity 6 (CAS 116601-09-3)
- Varenicline Impurity 22 (CAS 1213781-59-9)
- Varenicline Impurity 31 (CAS 1333145-89-3)
- Varenicline Impurity 16 (CAS 1337563-47-9)
- Varenicline Impurity 70 (CAS 1337563-47-9 (free base))
- Varenicline Impurity 23 (CAS 1350219-74-7)
- Varenicline-d4 (CAS 2183239-01-0)
Recommended Standards
- LCZ-696 Impurity 16 (CAS 1639970-62-9)
- Acotiamide Impurity 12 (CAS CATO-C4X-111412)
- Urapidil impurity 98 (CAS 91453-03-1（free base)）)
- 6-Methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 7154-45-2)
- (1E)-N-(3,5-Dimethylphenyl)-1-[1-(4-methoxyphenyl)-4-[(4-methylphenyl)sulfanyl]-2-phenyl-6,7-dihydro-1H-indol-5-yl]methanimine (CAS 477869-28-6)
- 6-(P-tolyl)imidazo[2,1-b]thiazol-5-amine (CAS 94802-81-0)
- 2-(2-Methyl-4-nitro-1H-imidazol-1-yl)acetamide (CAS 120799-99-7)
- 4-Amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol (CAS 869734-20-3)
- 3-Bromo-2-iodotoluene (CAS 869500-07-2)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
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