Tert-butyl (3R,6S)-1,1-difluoro-6-(hydroxymethyl)-5-azaspiro[2.4]Heptane-5-carboxylate CAS 2306255-50-3
| CAS No. | 2306255-50-3 |
| Molecular Formula | C12H19F2NO3 |
| Molecular Weight | 263.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tert-butyl (3R,6S)-1,1-difluoro-6-(hydroxymethyl)-5-azaspiro[2.4]Heptane-5-carboxylate.
CATO supplies Tert-butyl (3R,6S)-1,1-difluoro-6-(hydroxymethyl)-5-azaspiro[2.4]Heptane-5-carboxylate (CAS 2306255-50-3), a certified reference material (molecular formula C12H19F2NO3, MW 263.28 g/mol) for analytical method development and quality control.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Tert-butyl (3R,6S)-1,1-difluoro-6-(hydroxymethyl)-5-azaspiro[2.4]Heptane-5-carboxylate is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 263.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19F2NO3 |
| Molecular Weight | 263.28 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 2-(Bis(4-fluorophenyl)methoxy)ethan-1-amine (CAS 50366-32-0)
- Tert-butyl (3S,6S)-1,1-difluoro-6-(hydroxymethyl)-5-azaspiro[2.4]Heptane-5-carboxylate (CAS 2306249-09-0)
- 1-[(1-Methyl-1H-imidazol-2-yl)sulfonyl]-1H-benzotriazole (CAS 678173-46-1)
- tert-Butyl 4-(difluoromethyl)-1-(hydroxymethyl)-2-azabicyclo[2.1.1]hexane-2-carboxylate (CAS 2649757-01-5)
- Oxiracetam (CAS 62613-82-5)
- n-(3-Bromo-4-fluorobenzyl)-2-(1h-pyrazol-1-yl)ethan-1-amine (CAS 1293072-18-0)
- 2-Chloroethyl carbamate (CAS 2114-18-3)
- (1R,5S,9S)-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol (CAS 785762-60-9)
- 1-Chloro-3-fluoro-5-(trifluoromethyl)benzene (CAS 1005764-23-7)
- Olanzapine 4'-N-Glucuronide (CAS 186792-79-0)
- 2,2-Dimethyl-3-butenoic Acid Methyl Ester (CAS 19757-86-9)
- Ramelteon-d3 (CAS 1432057-38-9)
- Tetrahydro-2H-pyran-2,5-dicarboxylic acid (CAS 101012-23-1)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com