5-chloro-3-isopropoxy-1,6-naphthyridine-2-carbonitrile CAS 2306264-12-8
| CAS No. | 2306264-12-8 |
| Molecular Formula | C12H20ClN3O |
| Molecular Weight | 257.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-chloro-3-isopropoxy-1,6-naphthyridine-2-carbonitrile (CAS 2306264-12-8), molecular formula C12H20ClN3O and molecular weight 257.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-chloro-3-isopropoxy-1,6-naphthyridine-2-carbonitrile (C12H20ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-chloro-3-isopropoxy-1,6-naphthyridine-2-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H20ClN3O |
| Molecular Weight | 257.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
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- 5-((2-Chlorobenzyl)thio)-1,3,4-thiadiazol-2(3h)-imine (CAS 299442-99-2)
- 2-[4-(8-Bromo-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl]-2-methylpropionitrile (CAS 915019-50-0)
- TX 1-85-1 (CAS 1603845-32-4)
- 3-Ethoxy-2-ethyl-N-(4-phenylbutyl)-2H-indazole-6-carboxamide (CAS 919108-87-5)
- 1-[(2-Chlorophenyl)sulfanyl]-N-{1-[(3,4-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridin-3-yl}formamide (CAS 338783-91-8)
- Fmoc-Ala-Val-OH (CAS CATO-CPTD788764)
- tert-Butyl 4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylate (CAS 1445950-77-5)
- 1-(3,5-Dimethylisoxazole-4-carbonyl)pyrrolidine-3-carboxylic acid (CAS 1283525-15-4)
- N-(4-Ethoxyphenyl)-3,4-dihydro-2H-pyrrol-5-amine (CAS 321945-55-5)
- 6-Isopropylnicotinic acid (CAS 886214-81-9)
- C-Peptide（dog） (CAS 39016-05-2)
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