5-Chlorobenzofuran-2-carbaldehyde CAS 23145-14-4
| CAS No. | 23145-14-4 |
| Molecular Formula | C9H5ClO2 |
| Molecular Weight | 180.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chlorobenzofuran-2-carbaldehyde.
5-Chlorobenzofuran-2-carbaldehyde (CAS 23145-14-4), molecular formula C9H5ClO2 and molecular weight 180.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chlorobenzofuran-2-carbaldehyde (C9H5ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chlorobenzofuran-2-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5ClO2 |
| Molecular Weight | 180.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
Related Chlorobenzofuran Standards
- (7-Chlorobenzofuran-3-yl)methanamine (CAS 1506587-95-6)
- (5-Chlorobenzofuran-2-yl)methanamine (CAS 165735-64-8)
- (4-Chlorobenzofuran-3-yl)methanamine (CAS 1824406-12-3)
- (6-Chlorobenzofuran-2-yl)methanol (CAS 1089682-04-1)
- (5-Chlorobenzofuran-3-yl)methanol (CAS 650616-58-3)
- 7-Chlorobenzofuran-5-carbonitrile (CAS 1427420-85-6)
- 7-chlorobenzofuran-4-ol (CAS 1195621-52-3)
- 6-chlorobenzofuran-7-amine (CAS 379230-43-0)
Recommended Standards
- 5-Chloro-3H-quinazolin-4-one (CAS 60233-66-1)
- 5-Chlorocinnolin-3(2H)-one (CAS 23063-07-2)
- 5-chloro-2-nitro-pyridin-3-ol (CAS 936247-35-7)
- 5-Chloroimidazo[1,2-a]pyridine-2-carbaldehyde (CAS 881841-35-6)
- 1-(3-Ethoxy-phenyl)-piperazine (CAS 89989-06-0)
- (2-Chloro-2-methylpropyl)benzene (CAS 1754-74-1)
- 2,2′-Bipyridine, 5-bromo-5′-methyl- (CAS 1187163-83-2)
- 2-(5-Amino-2-pyridyl)-2-methylpropanenitrile (CAS 1226776-95-9)
- 5,5-Difluoro-2-azabicyclo[2.2.2]octane (CAS 1214875-50-9)
- 3-(Pyridin-3-yl)-2-tosylacrylonitrile (CAS 897296-66-1)
- tert-Butyl 4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)azepane-1-carboxylate (CAS 2694027-99-9)
- 6-Fluoro-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (CAS 1884412-16-1)
- (S)-4,5,6,7-Tetrahydro-1H-indazol-7-amine (CAS 2381462-18-4)
- D-Pro38-Tirzepatide (CAS CATO-CPTD788901)
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