4-Chloro-2-methylphenyl isothiocyanate CAS 23165-53-9
| CAS No. | 23165-53-9 |
| Molecular Formula | C8H6ClNS |
| Molecular Weight | 183.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 183.66 g/mol gives 4-Chloro-2-methylphenyl isothiocyanate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloro-2-methylphenyl isothiocyanate (CAS 23165-53-9) is a high-purity analytical reference standard with the molecular formula C8H6ClNS and a molecular weight of 183.66 g/mol.
The molecular framework of 4-Chloro-2-methylphenyl isothiocyanate (C8H6ClNS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Chloro-2-methylphenyl isothiocyanate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClNS |
| Molecular Weight | 183.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-(methylsulfanyl)benzonitrile (CAS 1002557-03-0)
- 5-Chloro-2-methylbenzothiazole (CAS 1006-99-1)
- 7-Chloro-5-methylthieno[3,2-b]pyridine (CAS 1211582-14-7)
- 4-Chloro-3-methylthieno[3,2-c]pyridine (CAS 1315362-03-8)
- 1-Chloro-n-cyclopropyl-n-methylmethanesulfonamide (CAS 1343803-65-5)
- 5-Chloro-3-methylthieno[3,2-b]pyridine (CAS 1356016-33-5)
- 4-Chloro-6-methyl-thieno[2,3-b]pyridine (CAS 1824285-22-4)
- 2-Chloro-6-methylphenyl isothiocyanate (CAS 19241-34-0)
Recommended Standards
- 4-Chloro-2-methylbenzo[d]thiazole (CAS 4146-23-0)
- 4-Chloro-2-methylthieno[3,2-c]pyridine (CAS 59207-24-8)
- 3-Chlorobenzyl thiocyanate (CAS 64215-09-4)
- 4-Chlorobenzyl isothiocyanate (CAS 3694-45-9)
- 3-Methyl-4-(pyrrolidine-1-carbonyl)aniline (CAS 325125-06-2)
- 5'-(2-Formylphenyl)-[1,1':3',1''-terphenyl]-2,2''-dicarbaldehyde (CAS 87226-90-2)
- 3-(2-Oxoacetyl)benzonitrile (CAS 105802-54-8)
- N-(2-Morpholino-2-(thiophen-3-yl)ethyl)cyclopropanecarboxamide (CAS 946272-28-2)
- Baicalein-6-O-glucoside (CAS 28279-72-3)
- (R)-3-(((benzyloxy)carbonyl)(methyl)amino)butanoic acid (CAS 2171202-69-8)
- 1'-Methyl-3,4-dihydrospiro[1-benzopyran-2,4'-piperidin]-4-amine (CAS 70505-90-7)
- N-Propylpyridin-4-amine (CAS 179339-90-3)
- 3-(2-{[(tert-butoxy)carbonyl]amino}propan-2-yl)-1,2-oxazole-4-carboxylic acid (CAS 1803589-24-3)
- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
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