阿法替尼杂质QJJ CAS 2323570-72-3
| CAS No. | 2323570-72-3 |
| Molecular Formula | C24H27ClFN5O4 |
| Molecular Weight | 503.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, 阿法替尼杂质QJJ (CAS 2323570-72-3, C24H27ClFN5O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 阿法替尼杂质QJJ is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 503.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H27ClFN5O4 |
| Molecular Weight | 503.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Recommended Standards
- N-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}pyridin-3-yl)thiophene-2-sulfonamide (CAS 338411-80-6)
- 5-Chloro-1-cyclopropyl-6,7-bis(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 1624261-25-1)
- Cefdinir Impurity 79 (CAS 116856-25-8)
- (Z)-{2-[(4-chlorophenyl)sulfanyl]-1-{2,7-dimethylimidazo[1,2-a]pyridin-3-yl}ethylidene}({[3-(trifluoromethyl)phenyl]methoxy})amine (CAS 383148-22-9)
- Azelastine impurity 62 (CAS CATO-C4X-139662)
- Minoxidil Impurity 22 (CAS 56488-00-7)
- Deflazacort Impurity 5 (CAS 1425664-43-2)
- 2-(Benzo[d]thiazol-2-yl)-1,3,4-oxadiazole (CAS 55439-42-4)
- (S)-3-((tert-Butoxycarbonyl)amino)-2-(pyridin-2-ylmethyl)propanoic acid (CAS 1240588-75-3)
- 5-(Tert-butyl)-2-(cyclopropylmethoxy)benzaldehyde (CAS 883514-34-9)
- 5,5',5'',5'''-Silanetetrayltetraisophthalic acid (CAS 1412999-57-5)
- 5,7-Dichlorobenzo[d]thiazol-2-amine (CAS 158465-13-5)
- 1-(5,7-Dinitroindolin-1-yl)ethan-1-one (CAS 62796-78-5)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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