Thalidomide-O-acetamido-C5-acid CAS 2354352-06-8
| CAS No. | 2354352-06-8 |
| Molecular Formula | C21H23N3O8 |
| Molecular Weight | 445.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Thalidomide-O-acetamido-C5-acid (CAS 2354352-06-8), molecular formula C21H23N3O8 and molecular weight 445.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Thalidomide-O-acetamido-C5-acid (C21H23N3O8) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H23N3O8 |
| Molecular Weight | 445.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 3 |
Related Thalidomide Standards
- Thalidomide-NH-C4-NH-Boc (CAS 2093388-52-2)
- Thalidomide-O-PEG3-propargyl (CAS 2098799-76-7)
- Thalidomide-O-acetamido-PEG1-C2-acid (CAS 2204225-99-8)
- Thalidomide-NH-C2-PEG3-OH (CAS 2140807-23-2)
- Thalidomide-NH-C10-COOH (CAS 2428400-33-1)
- Thalidomide-O-amido-C8-NH2 (CAS 1950635-15-0)
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- Thalidomide-O-amido-C6-NH2 (CAS 1950635-13-8)
Recommended Standards
- C646 (CAS 328968-36-1)
- Folic Acid-d4 (CAS 171777-72-3)
- 3-Chloro-4-pyridylcycloheptyl ketone (CAS 898785-24-5)
- (3E)-3-[(2-{[3-(trifluoromethyl)phenyl]methoxy}naphthalen-1-yl)methylidene]-2,3-dihydro-1H-indol-2-one (CAS 866138-27-4)
- 6,7-Dimethylquinoxaline (CAS 7153-23-3)
- N-(3-bromophenyl)piperidin-4-amine dihydrochloride (CAS 1229624-95-6)
- Ethyl 2-(trifluoromethyl)furan-3-carboxylate (CAS 23584-63-6)
- 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (CAS 18194-24-6)
- 2-Chloro-N-(4-methyl-5-(4-methylbenzyl)thiazol-2-yl)acetamide (CAS 1354950-90-5)
- 5-amino-2,6-dihydrotriazolo[4,5-d]pyrimidin-7-one (CAS 1850358-61-0)
- 4-Methoxyquinoline-7-carboxylic acid (CAS 1956335-60-6)
- 2-((Tetrahydrothiophen-3-yl)oxy)isonicotinamide (CAS 2034497-94-2)
- (6-Ethyl-3-methoxypyridin-2-yl)methanamine hydrochloride (CAS 1824097-71-3)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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