4,4-Difluorospiro[2.2]pentane-1-carboxylic acid CAS 2361635-28-9
| CAS No. | 2361635-28-9 |
| Molecular Formula | C6H6F2O2 |
| Molecular Weight | 148.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4,4-Difluorospiro[2.2]pentane-1-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4,4-Difluorospiro[2.2]pentane-1-carboxylic acid (CAS 2361635-28-9), molecular formula C6H6F2O2 and molecular weight 148.11 g/mol, is a CATO reference standard with documented purity and traceability.
4,4-Difluorospiro[2.2]pentane-1-carboxylic acid (C6H6F2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H6F2O2 |
| Molecular Weight | 148.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
Related Difluorospiro Standards
- 2,2-Difluorospiro[2.2]pentane-1-carboxylic acid (CAS 2193061-40-2)
- (1,1-Difluorospiro[2.3]Hexan-5-yl)methanol (CAS 2090653-93-1)
- (2,2-Difluorospiro[2.3]Hexan-1-yl)methanol (CAS 2166779-81-1)
- 6,6-Difluorospiro[3.3]Heptan-2-ol (CAS 2408974-56-9)
- 6,6-Difluorospiro[3.3]heptan-2-amine (CAS 1354952-13-8)
- (1,1-Difluorospiro[2.3]hexan-5-yl)methanamine (CAS 2092051-33-5)
- 2,2-difluorospiro[2.3]hexane-5-carbaldehyde (CAS 2411246-39-2)
- 2,2-difluorospiro[3.3]heptan-6-one (CAS 2137641-05-3)
Recommended Standards
- 3-Ethoxy-2-hydroxy-3-oxopropanoic acid (CAS 221250-27-7)
- Dimethyl 2-hydroxymalonate (CAS 34259-29-5)
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- (3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-one 1,4-D-Arabinonolactone 2782-09-4 CHEBI:16292 D-Arabinonic acid, gamma-lactone D-Arabonolactone D-arabinono-1,4-lactone (CAS 2782-09-4)
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxamide (CAS 1823921-49-8)
- (2R,3R,4S,5S)-5-(Hydroxymethyl)tetrahydrofuran-2,3,4-triol (CAS 40461-89-0)
- 1-Cyclobutylpiperidin-4-amine (CAS 1048921-27-2)
- 2-(Aminomethyl)-3-cyano-4-(difluoromethyl)-6-fluoropyridine (CAS 1804485-53-7)
- 5-Chloro-2-morpholinothiazole-4-carboxylic acid (CAS 1403568-17-1)
- 2-(1,4-Diazepan-1-yl)-N-(2,3-dihydro-1H-inden-5-yl)acetamide (CAS 1097813-82-5)
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- tert-Butyl (4-bromo-3-cyanobenzo[b]thiophen-2-yl)carbamate (CAS 2649788-75-8)
- Tirzepatide Impurity 19 X TFA Salt (CAS CATO-C4X-324019)
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