Glimepiride EP Impurity E CAS 2366968-77-4
| CAS No. | 2366968-77-4 |
| Molecular Formula | C16H21N3O4S |
| Molecular Weight | 351.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Glimepiride EP Impurity E is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Glimepiride EP Impurity E (CAS 2366968-77-4) is a certified pharmaceutical impurity reference standard with the molecular formula C16H21N3O4S and a molecular weight of 351.42 g/mol.
Glimepiride EP Impurity E (C16H21N3O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H21N3O4S |
| Molecular Weight | 351.42 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Glimepiride Standards
- Glimepiride EP Impurity B (CAS 119018-29-0)
- Glimepiride EP Impurity J (CAS 41176-98-1)
- Glimepiride Impurity 9 (CAS 119043-16-2)
- Glimepiride EP Impurity C (CAS 119018-30-3)
- Glimepiride EP Impurity F (CAS CATO-C4X-11026)
- Glimepiride Impurity 12 (CAS 318515-70-7)
- Glimepiride EP Impurity G (CAS CATO-C4X-11027)
- Glimepiride Impurity 15 (CAS 247098-18-6)
Recommended Standards
- 4,5-Dihydro Cefradine Impurity (CAS 37051-00-6)
- N-(5-Oxido-2-phenyl-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenylacetamide (CAS 957624-87-2)
- 2-((5-(1,5-Dimethyl-1h-pyrazol-3-yl)-4-((tetrahydrofuran-2-yl)methyl)-4h-1,2,4-triazol-3-yl)thio)acetohydrazide (CAS 1006326-97-1)
- N-(3-{3-[4-(4-Fluorophenyl)piperazino]-1-propynyl}phenyl)acetamide (CAS 900015-38-5)
- Bilastine impurity 95 (CAS CATO-C4X-225395)
- Regadenoson Impurity 28 (CAS 3868-34-6)
- Raltitrexed Impurity 5 (CAS 4282-31-9)
- methyl 3,5-dimethylfuran-2-carboxylate (CAS 34883-95-9)
- n-Ethyladamantan-2-amine (CAS 46176-57-2)
- 2,4-difluoro-1-propyl-1H-1,3-benzodiazole (CAS 2300831-06-3)
- 3-(Methylsulfonyl)propyl 4-Methylbenzenesulfonate (CAS 263400-88-0)
- 1-[4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2-yl]ethan-1-amine (CAS 642929-46-2)
- (R)-1-BENZYL-3-METHYLPIPERAZINE (CAS 132871-11-5)
- Peptide 433 (CAS CATO-CPTD788433)
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