Methyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate CAS 237385-98-7
| CAS No. | 237385-98-7 |
| Molecular Formula | C13H9F3O2S |
| Molecular Weight | 286.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate (C13H9F3O2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Methyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate (CAS 237385-98-7) is a high-purity analytical reference standard with the molecular formula C13H9F3O2S and a molecular weight of 286.27 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9F3O2S |
| Molecular Weight | 286.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2024 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Recommended Standards
- Ethyl 2-[4-(2-Ethoxy-2-oxoethyl)phenyl]-2,2-difluoroacetate (CAS 2006277-16-1)
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- Diethyl 2-fluoro-2-(((methylsulfonyl)oxy)methyl)malonate (CAS 2710-86-3)
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- 2,2,2-Trifluoro-1-(4-methylpyridin-2-yl)ethan-1-one (CAS 1060804-97-8)
- Avibactam Impurity 71 (CAS CATO-C4X-134871)
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- Peptide Impurity 24 (CAS CATO-CPTD788824)
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