rel-tert-Butyl (1R,2R,3R,5S)-3-amino-2-fluoro-8-azabicyclo[3.2.1]octane-8-carboxylate CAS 2375919-22-3
| CAS No. | 2375919-22-3 |
| Molecular Formula | C12H21FN2O2 |
| Molecular Weight | 244.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
rel-tert-Butyl (1R,2R,3R,5S)-3-amino-2-fluoro-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 2375919-22-3), molecular formula C12H21FN2O2 and molecular weight 244.31 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of rel-tert-Butyl (1R,2R,3R,5S)-3-amino-2-fluoro-8-azabicyclo[3.2.1]octane-8-carboxylate (C12H21FN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H21FN2O2 |
| Molecular Weight | 244.31 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- n-Tert-butyl-6-hydrazinylpyridine-3-sulfonamide (CAS 926262-36-4)
- rel-tert-Butyl (1R,2S,3R,5S)-3-amino-2-fluoro-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 2375918-49-1)
- N-Desmethyl-N-hydroxymethyl Tebuthiuron (CAS 59962-54-8)
- tert-Butyl ((1R,2R,3S,5S)-2-fluoro-8-azabicyclo[3.2.1]octan-3-yl)carbamate (CAS 2375919-35-8)
- 4-chloro-8-methoxy-2-methyl-quinazoline (CAS 154288-17-2)
- (Phenylmethylene)carbamic acid tert-butyl ester (CAS 150884-50-7)
- Methyl 5-fluoro-6-(3-oxoazetidin-1-yl)nicotinate (CAS 2165357-45-7)
- 3-(3-Bromophenyl)picolinic acid (CAS 1344701-75-2)
- 6-(2,4-Dichlorophenyl)pyridazin-3-ol (CAS 58897-72-6)
- 4-Bromo-N-isopropylpyridazin-3-amine (CAS 1396762-46-1)
- 2-(4-Isopropylphenyl)ethanol (CAS 10099-57-7)
- 5-((2-Fluorobenzyl)oxy)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)-4H-pyran-4-one (CAS 898440-23-8)
- 4-Iodo-N,N-dimethyl-1H-pyrazole-1-sulfonamide (CAS 188978-36-1)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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