5-(4-Nitrophenyl)-1,3,4-oxadiazole-2(3H)-thione CAS 23766-30-5
| CAS No. | 23766-30-5 |
| Molecular Formula | C8H5N3O3S |
| Molecular Weight | 223.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 5-(4-Nitrophenyl)-1,3,4-oxadiazole-2(3H)-thione (CAS 23766-30-5), a certified reference material (molecular formula C8H5N3O3S, MW 223.21 g/mol) for analytical method development and quality control.
The molecular framework of 5-(4-Nitrophenyl)-1,3,4-oxadiazole-2(3H)-thione (C8H5N3O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5N3O3S |
| Molecular Weight | 223.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Nitrophenyl Standards
- 5-(3-Nitrophenyl)-1,3,4-oxadiazole-2-thiol (CAS 41421-07-2)
- 5-(4-Nitrophenyl)-1,3,4-thiadiazol-2(3H)-one (CAS 97051-26-8)
- 2-(4-Nitrophenyl)pentanoic acid (CAS 110728-99-9)
- 2-(4-Methyl-3-nitrophenyl)-1,3-dioxane (CAS 1212060-78-0)
- 2-[(4-nitrophenyl)methyl]butanoic acid (CAS 1248983-13-2)
- 2-Methyl-4-(2-nitrophenyl)butanoic acid (CAS 1343120-59-1)
- 4-Nitrophenyl Pentanoate (CAS 1956-07-6)
- 1-(2-Nitrophenyl)-3-(propan-2-yl)urea (CAS 347907-99-7)
Recommended Standards
- 5-(3-Nitrophenoxy)-1,2,3-thiadiazole (CAS 338421-21-9)
- 5-Nitrobenzothiophene-2-carboxylic Acid (CAS 6345-55-7)
- 4-Nitro-benzo[b]thiophene-2-carboxylic acid (CAS 19995-46-1)
- 6-Amino-7-dimethylphosphoryl-indan-1-one (CAS 2267330-81-2)
- 5-(3,4-Difluorophenoxy)pentanenitrile (CAS 1250563-08-6)
- 3,6-DIMETHYLIMIDAZO[1,2-A]PYRIDINE (CAS 78132-62-4)
- 4-(2-Chloro-5-methylphenoxy)-3-fluoroaniline (CAS 946742-32-1)
- 1-(2-Bromophenyl)-5-methyl-1H-pyrazole (CAS 1248277-26-0)
- Entacapone Impurity 24 (CAS 4097-63-6)
- Cefpirome Impurity 17 (CAS CATO-C4X-120717)
- Cyclopentyl(2,6-difluorophenyl)methanone (CAS 1339769-34-4)
- Methyl 1-(2-(3-amino-2-oxopyridin-1(2H)-yl)ethyl)pyrrolidine-3-carboxylate (CAS 2171110-49-7)
- 2-(6-Chloro-5-(difluoromethyl)-3-methylpyridin-2-yl)acetonitrile (CAS 1804664-36-5)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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